Novel Sensors for Batch and Flow Injection Analysis of Histamine Based on Crown Ethers

Six types of histamine potentiometric sensors are developed. They are based on using dibenzo-30-crown-10 (DB30C10) with potassium tetrakis(p-chlorophenyl)borate lipophilic additive (Type I), dibenzo-30-crown-10 without additive (Type II), dibenzo-24-crown-8 (DB24C8) with the same additive (Type III), dibenzo-24-crown-8 without additive (Type IV), dibenzo-18-crown-6 with the additive (Type V) and dibenzo-18-crown-6 without additive (Type VI) as neutral carriers for histamine. Sensors based on dibenzo-30-crown-10 with (PTp-C1PB) lipophilic additive (Type I) and dibenzo-30-crown-10 without additive (Type II) show good response. The other sensors Types III-VI show poor response in terms of calibration range and slope.