TY - JOUR
T1 - Non-coding RNAs
T2 - Key regulators of CDK and Wnt/β-catenin signaling in cancer
AU - Shaikh, Mohammad Arshad Javed
AU - Babu, M. Arockia
AU - Ghaboura, Nehmat
AU - Altamimi, Abdulmalik S.A.
AU - Sharma, Pawan
AU - Rani, Richa
AU - Rani, G. B.
AU - Lakhanpal, Sorabh
AU - Ali, Haider
AU - Balaraman, Ashok Kumar
AU - Rawat, Sushama
AU - Alzarea, Sami I.
AU - Kazmi, Imran
N1 - Publisher Copyright:
Copyright © 2024 Elsevier GmbH. All rights reserved.
PY - 2024/11/1
Y1 - 2024/11/1
N2 - Non-coding RNAs (ncRNAs) have become important modulators of gene expression and biological processes, contributing significantly to the initiation and spread of cancer. This study focuses on the complex interactions between ncRNAs and two major signaling pathways-Wnt/β-catenin signaling and cyclin-dependent kinase (CDK)-linked to cancer. We provide an overview of current research on the modulation of these pathways in many cancer types by distinct classes of ncRNAs, such as miRNAs, lncRNAs, and circRNAs. The review focuses on the processes by which ncRNAs regulate cancer cell survival, proliferation, and metastasis. These mechanical processes include CDK activity, the activation of the Wnt/β-catenin cascade and cell cycle advancement. We also discuss the importance of ncRNAs in drug resistance and treatment outcomes, as well as prognosis markers (diagnostic) and therapeutic targets for cancer. Understanding these complex regulatory networks may help in a large way to improve cancer research and diagnosis - but also perhaps treat patients more effectively.
AB - Non-coding RNAs (ncRNAs) have become important modulators of gene expression and biological processes, contributing significantly to the initiation and spread of cancer. This study focuses on the complex interactions between ncRNAs and two major signaling pathways-Wnt/β-catenin signaling and cyclin-dependent kinase (CDK)-linked to cancer. We provide an overview of current research on the modulation of these pathways in many cancer types by distinct classes of ncRNAs, such as miRNAs, lncRNAs, and circRNAs. The review focuses on the processes by which ncRNAs regulate cancer cell survival, proliferation, and metastasis. These mechanical processes include CDK activity, the activation of the Wnt/β-catenin cascade and cell cycle advancement. We also discuss the importance of ncRNAs in drug resistance and treatment outcomes, as well as prognosis markers (diagnostic) and therapeutic targets for cancer. Understanding these complex regulatory networks may help in a large way to improve cancer research and diagnosis - but also perhaps treat patients more effectively.
KW - Cyclin-dependent kinase
KW - Gene expression
KW - NcRNAs
KW - Prognosis markers
KW - Wnt/β-catenin
UR - https://www.scopus.com/pages/publications/85208688713
U2 - 10.1016/j.prp.2024.155659
DO - 10.1016/j.prp.2024.155659
M3 - Review article
C2 - 39461246
AN - SCOPUS:85208688713
SN - 0344-0338
VL - 263
SP - 155659
JO - Pathology Research and Practice
JF - Pathology Research and Practice
ER -
