New phenolic glycosides with cyclooxygenase inhibition from the roots of Tecoma mollis

Wael M. Abdel-Mageed; Lamya H. Al-Wahaibi; Enaam Y. Backheet; Ali A. El-Gamal; Yaser G. Gouda; Omer A. Basudan; Maged S. Abdel-Kader; Azza A. Khalifa

doi:10.1016/j.phytol.2017.06.011

New phenolic glycosides with cyclooxygenase inhibition from the roots of Tecoma mollis

Wael M. Abdel-Mageed
, Lamya H. Al-Wahaibi
, Enaam Y. Backheet
, Ali A. El-Gamal
, Yaser G. Gouda
, Omer A. Basudan
, Maged S. Abdel-Kader
, Azza A. Khalifa

Fharmacognosy

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Three new phenolic glycosides (1–3) together with nine known ones were isolated from the roots of Tecoma mollis using DPPH radical scavenging bioassay-guided chromatographic separation. The structures of the new compounds were established using extensive spectroscopic data and HR-MS. The antioxidant, COX-2 inhibition, and cytotoxic activities were evaluated for the isolated compounds. Compound 4 displayed the strongest radical scavenging activity relative to ascorbic acid with IC₅₀ 8.7 μM. Compounds 5, 6, and 10 showed promising COX-2 inhibitory action, IC₅₀ values of 11.3 μM, 9.4 μM, and 13.4 μM, respectively. All compounds exhibited weak cytotoxic activity against Hela and A549 cancer cell lines.

Original language	English
Pages (from-to)	98-103
Number of pages	6
Journal	Phytochemistry Letters
Volume	21
DOIs	https://doi.org/10.1016/j.phytol.2017.06.011
State	Published - Sep 2017

Keywords

Cycloxygenase inhibition activity
Cytotoxicity
Phenolic glycosides
Phenylpropanoids
Radical scavenging activity
Tecoma mollis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytol.2017.06.011

Cite this

@article{58063bcc02514346bb6f52b89750d48a,

title = "New phenolic glycosides with cyclooxygenase inhibition from the roots of Tecoma mollis",

abstract = "Three new phenolic glycosides (1–3) together with nine known ones were isolated from the roots of Tecoma mollis using DPPH radical scavenging bioassay-guided chromatographic separation. The structures of the new compounds were established using extensive spectroscopic data and HR-MS. The antioxidant, COX-2 inhibition, and cytotoxic activities were evaluated for the isolated compounds. Compound 4 displayed the strongest radical scavenging activity relative to ascorbic acid with IC50 8.7 μM. Compounds 5, 6, and 10 showed promising COX-2 inhibitory action, IC50 values of 11.3 μM, 9.4 μM, and 13.4 μM, respectively. All compounds exhibited weak cytotoxic activity against Hela and A549 cancer cell lines.",

keywords = "Cycloxygenase inhibition activity, Cytotoxicity, Phenolic glycosides, Phenylpropanoids, Radical scavenging activity, Tecoma mollis",

author = "Abdel-Mageed, \{Wael M.\} and Al-Wahaibi, \{Lamya H.\} and Backheet, \{Enaam Y.\} and El-Gamal, \{Ali A.\} and Gouda, \{Yaser G.\} and Basudan, \{Omer A.\} and Abdel-Kader, \{Maged S.\} and Khalifa, \{Azza A.\}",

note = "Publisher Copyright: {\textcopyright} 2017 Phytochemical Society of Europe",

year = "2017",

month = sep,

doi = "10.1016/j.phytol.2017.06.011",

language = "English",

volume = "21",

pages = "98--103",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - New phenolic glycosides with cyclooxygenase inhibition from the roots of Tecoma mollis

AU - Abdel-Mageed, Wael M.

AU - Al-Wahaibi, Lamya H.

AU - Backheet, Enaam Y.

AU - El-Gamal, Ali A.

AU - Gouda, Yaser G.

AU - Basudan, Omer A.

AU - Abdel-Kader, Maged S.

AU - Khalifa, Azza A.

PY - 2017/9

Y1 - 2017/9

N2 - Three new phenolic glycosides (1–3) together with nine known ones were isolated from the roots of Tecoma mollis using DPPH radical scavenging bioassay-guided chromatographic separation. The structures of the new compounds were established using extensive spectroscopic data and HR-MS. The antioxidant, COX-2 inhibition, and cytotoxic activities were evaluated for the isolated compounds. Compound 4 displayed the strongest radical scavenging activity relative to ascorbic acid with IC50 8.7 μM. Compounds 5, 6, and 10 showed promising COX-2 inhibitory action, IC50 values of 11.3 μM, 9.4 μM, and 13.4 μM, respectively. All compounds exhibited weak cytotoxic activity against Hela and A549 cancer cell lines.

AB - Three new phenolic glycosides (1–3) together with nine known ones were isolated from the roots of Tecoma mollis using DPPH radical scavenging bioassay-guided chromatographic separation. The structures of the new compounds were established using extensive spectroscopic data and HR-MS. The antioxidant, COX-2 inhibition, and cytotoxic activities were evaluated for the isolated compounds. Compound 4 displayed the strongest radical scavenging activity relative to ascorbic acid with IC50 8.7 μM. Compounds 5, 6, and 10 showed promising COX-2 inhibitory action, IC50 values of 11.3 μM, 9.4 μM, and 13.4 μM, respectively. All compounds exhibited weak cytotoxic activity against Hela and A549 cancer cell lines.

KW - Cycloxygenase inhibition activity

KW - Cytotoxicity

KW - Phenolic glycosides

KW - Phenylpropanoids

KW - Radical scavenging activity

KW - Tecoma mollis

UR - https://www.scopus.com/pages/publications/85021066263

U2 - 10.1016/j.phytol.2017.06.011

DO - 10.1016/j.phytol.2017.06.011

M3 - Article

AN - SCOPUS:85021066263

SN - 1874-3900

VL - 21

SP - 98

EP - 103

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

New phenolic glycosides with cyclooxygenase inhibition from the roots of Tecoma mollis

Abstract

Keywords

UN SDGs

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