New microbial source of the antifungal allylamine “Terbinafine”

Maged S. Abdel-Kader; Magdy Mohamed Muharram

doi:10.1016/j.jsps.2016.06.006

New microbial source of the antifungal allylamine “Terbinafine”

Maged S. Abdel-Kader, Magdy Mohamed Muharram

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The isolated active compound “F12” from the culture media of the Streptomyces sp. KH-F12 was identified using different spectroscopic techniques. Both 1D- and 2D-NMR as well as HRESIMS were utilized to characterize the structure of the isolated compound. ‘F12” was found to be the known systemic antifungal drug terbinafine marketed under the name “Lamisil”. Full analysis of the COSY, HSQC and HMBC enables the full assignment of proton and carbon atoms. Terbinafine is a synthetic allylamine and is reported here for the first time from natural source.

Original language	English
Pages (from-to)	440-442
Number of pages	3
Journal	Saudi Pharmaceutical Journal
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.jsps.2016.06.006
State	Published - 1 Mar 2017

Keywords

HRMS
NMR
Streptomyces sp.
Structure elucidation
Terbinafine

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10.1016/j.jsps.2016.06.006

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title = "New microbial source of the antifungal allylamine “Terbinafine”",

abstract = "The isolated active compound “F12” from the culture media of the Streptomyces sp. KH-F12 was identified using different spectroscopic techniques. Both 1D- and 2D-NMR as well as HRESIMS were utilized to characterize the structure of the isolated compound. {\textquoteleft}F12” was found to be the known systemic antifungal drug terbinafine marketed under the name “Lamisil”. Full analysis of the COSY, HSQC and HMBC enables the full assignment of proton and carbon atoms. Terbinafine is a synthetic allylamine and is reported here for the first time from natural source.",

keywords = "HRMS, NMR, Streptomyces sp., Structure elucidation, Terbinafine",

author = "Abdel-Kader, \{Maged S.\} and \{Mohamed Muharram\}, Magdy",

note = "Publisher Copyright: {\textcopyright} 2016 The Authors",

year = "2017",

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doi = "10.1016/j.jsps.2016.06.006",

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AU - Abdel-Kader, Maged S.

AU - Mohamed Muharram, Magdy

PY - 2017/3/1

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N2 - The isolated active compound “F12” from the culture media of the Streptomyces sp. KH-F12 was identified using different spectroscopic techniques. Both 1D- and 2D-NMR as well as HRESIMS were utilized to characterize the structure of the isolated compound. ‘F12” was found to be the known systemic antifungal drug terbinafine marketed under the name “Lamisil”. Full analysis of the COSY, HSQC and HMBC enables the full assignment of proton and carbon atoms. Terbinafine is a synthetic allylamine and is reported here for the first time from natural source.

AB - The isolated active compound “F12” from the culture media of the Streptomyces sp. KH-F12 was identified using different spectroscopic techniques. Both 1D- and 2D-NMR as well as HRESIMS were utilized to characterize the structure of the isolated compound. ‘F12” was found to be the known systemic antifungal drug terbinafine marketed under the name “Lamisil”. Full analysis of the COSY, HSQC and HMBC enables the full assignment of proton and carbon atoms. Terbinafine is a synthetic allylamine and is reported here for the first time from natural source.

KW - HRMS

KW - NMR

KW - Streptomyces sp.

KW - Structure elucidation

KW - Terbinafine

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DO - 10.1016/j.jsps.2016.06.006

M3 - Article

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VL - 25

SP - 440

EP - 442

JO - Saudi Pharmaceutical Journal

JF - Saudi Pharmaceutical Journal

IS - 3

ER -

New microbial source of the antifungal allylamine “Terbinafine”

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Keywords

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