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MiRNAs in Lung Cancer: Diagnostic, Prognostic, and Therapeutic Potential

  • Javaid Ahmad Wani
  • , Sabhiya Majid
  • , Zuha Imtiyaz
  • , Muneeb U. Rehman
  • , Rana M. Alsaffar
  • , Naveed Nazir Shah
  • , Sultan Alshehri
  • , Mohammed M. Ghoneim
  • , Syed Sarim Imam
  • Government Medical College Srinagar
  • Taipei Medical University
  • King Saud University
  • Prince Sattam Bin Abdulaziz University
  • Almaarefa University

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Lung cancer is the dominant emerging factor in cancer-related mortality around the globe. Therapeutic interventions for lung cancer are not up to par, mainly due to reoccurrence/relapse, chemoresistance, and late diagnosis. People are currently interested in miRNAs, which are small double-stranded (20–24 ribonucleotides) structures that regulate molecular targets (tumor suppressors, oncogenes) involved in tumorigeneses such as cell proliferation, apoptosis, metastasis, and angiogenesis via post-transcriptional regulation of mRNA. Many studies suggest the emerging role of miRNAs in lung cancer diagnostics, prognostics, and therapeutics. Therefore, it is necessary to intensely explore the miRNOME expression of lung tumors and the development of anti-cancer strategies. The current review focuses on the therapeutic, diagnostic, and prognostic potential of numerous miRNAs in lung cancer.

Original languageEnglish
Article number1610
JournalDiagnostics
Volume12
Issue number7
DOIs
StatePublished - Jul 2022
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • diagnostics
  • lung cancer
  • miRNA
  • therapeutics

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