TY - JOUR
T1 - Microwave-Assisted Synthesis of Novel Antimicrobial N-Arylated-Pyridopyrimidines
AU - Al-Tamimi, Abdul Malek S.
AU - Riadi, Yassine
N1 - Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - A facile and effective method to access to the N-arylated-pyridopyrimidines starting from 4-thiol or 4-chloropyridopyrimidines under microwave irradiation, is reported. The products were obtained via two different strategies providing both exellent yields. The major advantages of this process are the short reaction time, and high productivity as well as being eco-friendly. Moreover, the obtained derivatives were assessed against different bacterial strains. Three derivatives were found to be highly effective against both studied bacterial strains.
AB - A facile and effective method to access to the N-arylated-pyridopyrimidines starting from 4-thiol or 4-chloropyridopyrimidines under microwave irradiation, is reported. The products were obtained via two different strategies providing both exellent yields. The major advantages of this process are the short reaction time, and high productivity as well as being eco-friendly. Moreover, the obtained derivatives were assessed against different bacterial strains. Three derivatives were found to be highly effective against both studied bacterial strains.
KW - 4-chloropyridopyrimidines
KW - 4-thiol
KW - antibacterial activity
KW - microwave irradiation
KW - N-arylated- pyridopyrimidines
UR - https://www.scopus.com/pages/publications/85098593513
U2 - 10.1080/10406638.2020.1866041
DO - 10.1080/10406638.2020.1866041
M3 - Article
AN - SCOPUS:85098593513
SN - 1040-6638
VL - 42
SP - 3339
EP - 3347
JO - Polycyclic Aromatic Compounds
JF - Polycyclic Aromatic Compounds
IS - 6
ER -