Microwave-assisted Synthesis, Characterization, and Evaluation of Maleimide and Phthalimide Derivatives as an Antioxidant Agent

Because of the broad biological activities of phthalimide and maleimide derivatives, we synthesized a series of new phthalimide and maleimide derivatives for therapeutically active compounds by using the microwave-assisted synthesis method and evaluated them for in vitro antioxidant activity by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. All the synthesized compounds were characterized by UV, 1 H-NMR, and mass spectral analysis whereas TLC was performed to examine the completion of the reac-tions. The compound A₁ of the maleimide series and B₃ of the phthalimide series showed a higher percentage of practical yield, whereas compound A₃ of the maleimide series and B₄ of the phthalimide series exhibited higher antioxidant activity as compared to other compounds. These compounds were synthesized with the help of a microwave-assisted method and also exhibited considerable antioxidant activity. The compounds may also be further evaluated for other therapeutic benefits in animal models.