TY - JOUR
T1 - Mechanistic insights into the pathogenesis of neurodegenerative diseases
T2 - towards the development of effective therapy
AU - Nazam, Fauzia
AU - Shaikh, Sibhghatulla
AU - Nazam, Nazia
AU - Alshahrani, Abdulaziz Saad
AU - Hasan, Gulam Mustafa
AU - Hassan, Md Imtaiyaz
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2021/7
Y1 - 2021/7
N2 - Neurodegeneration is a prevalent and one of the emerging reasons for morbidity, mortality, and cognitive impairment in aging. Dementia is one of such conditions of neurodegeneration, partially manageable, irreversible, and worsens over time. This review is focused on biological and psychosocial risk factors associated with Alzheimer’s and Parkinson’s diseases, highlighting the value of cognitive decline. We further emphasized on current therapeutic strategies from pharmacological and non-pharmacological perspectives focusing on their effects on cognitive impairment, protein aggregation, tau pathology, and improving the quality of life. Deeper mechanistic insights into the multifactorial neurodegeneration could offer the design and development of promising diagnostic and therapeutic strategies.
AB - Neurodegeneration is a prevalent and one of the emerging reasons for morbidity, mortality, and cognitive impairment in aging. Dementia is one of such conditions of neurodegeneration, partially manageable, irreversible, and worsens over time. This review is focused on biological and psychosocial risk factors associated with Alzheimer’s and Parkinson’s diseases, highlighting the value of cognitive decline. We further emphasized on current therapeutic strategies from pharmacological and non-pharmacological perspectives focusing on their effects on cognitive impairment, protein aggregation, tau pathology, and improving the quality of life. Deeper mechanistic insights into the multifactorial neurodegeneration could offer the design and development of promising diagnostic and therapeutic strategies.
KW - Alzheimer’s disease; Parkinson’s disease
KW - Neurodegeneration
KW - Neurodegenerative diseases
KW - Therapeutic management
UR - http://www.scopus.com/inward/record.url?scp=85102377250&partnerID=8YFLogxK
U2 - 10.1007/s11010-021-04120-6
DO - 10.1007/s11010-021-04120-6
M3 - Review article
C2 - 33687588
AN - SCOPUS:85102377250
SN - 0300-8177
VL - 476
SP - 2739
EP - 2752
JO - Molecular and Cellular Biochemistry
JF - Molecular and Cellular Biochemistry
IS - 7
ER -
