Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives

A. S. El-Azab; H. A. Ghabbour; W. M. El-Husseiny; A. R. Maarouf; M. A. Mohamed; A. A.M. Abdel-Aziz

doi:10.1134/S1070363216120471

Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives

A. S. El-Azab
, H. A. Ghabbour
, W. M. El-Husseiny
, A. R. Maarouf
, M. A. Mohamed
, A. A.M. Abdel-Aziz

Pharmaceutical Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Hydrazones 2–22 were synthesized via the reaction of acetophenone with isatin derivatives and anhydrous hydrazine promoted by BF3 as a Lewis acid at 0°C. Structures of the synthesized hydrazones were determined on the basis of NMR and X-ray crystallographic analyses.

Original language	English
Pages (from-to)	2837-2844
Number of pages	8
Journal	Russian Journal of General Chemistry
Volume	86
Issue number	12
DOIs	https://doi.org/10.1134/S1070363216120471
State	Published - 1 Dec 2016

Keywords

BF3
efficient method
Lewis acids
N-unsubstituted hydrazone
X-ray crystal structure

Access to Document

10.1134/S1070363216120471

Cite this

@article{d33ad2582f58408195bcc54621cc654b,

title = "Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives",

abstract = "Hydrazones 2–22 were synthesized via the reaction of acetophenone with isatin derivatives and anhydrous hydrazine promoted by BF3 as a Lewis acid at 0°C. Structures of the synthesized hydrazones were determined on the basis of NMR and X-ray crystallographic analyses.",

keywords = "BF3, efficient method, Lewis acids, N-unsubstituted hydrazone, X-ray crystal structure",

author = "El-Azab, \{A. S.\} and Ghabbour, \{H. A.\} and El-Husseiny, \{W. M.\} and Maarouf, \{A. R.\} and Mohamed, \{M. A.\} and Abdel-Aziz, \{A. A.M.\}",

note = "Publisher Copyright: {\textcopyright} 2016, Pleiades Publishing, Ltd.",

year = "2016",

month = dec,

day = "1",

doi = "10.1134/S1070363216120471",

language = "English",

volume = "86",

pages = "2837--2844",

journal = "Russian Journal of General Chemistry",

issn = "1070-3632",

publisher = "Pleiades Publishing",

number = "12",

}

TY - JOUR

T1 - Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives

AU - El-Azab, A. S.

AU - Ghabbour, H. A.

AU - El-Husseiny, W. M.

AU - Maarouf, A. R.

AU - Mohamed, M. A.

AU - Abdel-Aziz, A. A.M.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Hydrazones 2–22 were synthesized via the reaction of acetophenone with isatin derivatives and anhydrous hydrazine promoted by BF3 as a Lewis acid at 0°C. Structures of the synthesized hydrazones were determined on the basis of NMR and X-ray crystallographic analyses.

AB - Hydrazones 2–22 were synthesized via the reaction of acetophenone with isatin derivatives and anhydrous hydrazine promoted by BF3 as a Lewis acid at 0°C. Structures of the synthesized hydrazones were determined on the basis of NMR and X-ray crystallographic analyses.

KW - BF3

KW - efficient method

KW - Lewis acids

KW - N-unsubstituted hydrazone

KW - X-ray crystal structure

UR - https://www.scopus.com/pages/publications/85015446938

U2 - 10.1134/S1070363216120471

DO - 10.1134/S1070363216120471

M3 - Article

AN - SCOPUS:85015446938

SN - 1070-3632

VL - 86

SP - 2837

EP - 2844

JO - Russian Journal of General Chemistry

JF - Russian Journal of General Chemistry

IS - 12

ER -

Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this