Intercalating Nucleic Acids: The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities

Ulf B. Christensen; Michael Wamberg; Farag A.G. El-Essawy; Abd El Hamid Ismail; Christina B. Nielsen; Vyacheslav V. Filichev; Carsten H. Jessen; Michael Petersen; Erik B. Pedersen

doi:10.1081/NCN-120027829

Intercalating Nucleic Acids: The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities

Ulf B. Christensen
, Michael Wamberg
, Farag A.G. El-Essawy
, Abd El Hamid Ismail
, Christina B. Nielsen
, Vyacheslav V. Filichev
, Carsten H. Jessen
, Michael Petersen
, Erik B. Pedersen

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Six new examples of intercalating nucleic acids were synthesized in order to evaluate the dependence of the length of the linker between oligo and intercalator on the thermal stability of their corresponding duplexes and triplexes.

Original language	English
Pages (from-to)	207-225
Number of pages	19
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	23
Issue number	1-2
DOIs	https://doi.org/10.1081/NCN-120027829
State	Published - 2004
Externally published	Yes

Keywords

7,9-Dimethylpyrido[3′,2′ :4,5]thieno[3,2-d] pyrimidine-4(1H)-one
DNA duplex stability of intercalating nucleic acids
Intercalating nucleic acids
Oligonucleotides with covalently bound intercalators
Pyrene intercalators

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10.1081/NCN-120027829

Cite this

Christensen, U. B., Wamberg, M., El-Essawy, F. A. G., Ismail, A. E. H., Nielsen, C. B., Filichev, V. V., Jessen, C. H., Petersen, M., & Pedersen, E. B. (2004). Intercalating Nucleic Acids: The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities. Nucleosides, Nucleotides and Nucleic Acids, 23(1-2), 207-225. https://doi.org/10.1081/NCN-120027829

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title = "Intercalating Nucleic Acids: The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities",

abstract = "Six new examples of intercalating nucleic acids were synthesized in order to evaluate the dependence of the length of the linker between oligo and intercalator on the thermal stability of their corresponding duplexes and triplexes.",

keywords = "7,9-Dimethylpyrido[3′,2′ :4,5]thieno[3,2-d] pyrimidine-4(1H)-one, DNA duplex stability of intercalating nucleic acids, Intercalating nucleic acids, Oligonucleotides with covalently bound intercalators, Pyrene intercalators",

author = "Christensen, \{Ulf B.\} and Michael Wamberg and El-Essawy, \{Farag A.G.\} and Ismail, \{Abd El Hamid\} and Nielsen, \{Christina B.\} and Filichev, \{Vyacheslav V.\} and Jessen, \{Carsten H.\} and Michael Petersen and Pedersen, \{Erik B.\}",

year = "2004",

doi = "10.1081/NCN-120027829",

language = "English",

volume = "23",

pages = "207--225",

journal = "Nucleosides, Nucleotides and Nucleic Acids",

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T2 - The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities

AU - Christensen, Ulf B.

AU - Wamberg, Michael

AU - El-Essawy, Farag A.G.

AU - Ismail, Abd El Hamid

AU - Nielsen, Christina B.

AU - Filichev, Vyacheslav V.

AU - Jessen, Carsten H.

AU - Petersen, Michael

AU - Pedersen, Erik B.

PY - 2004

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KW - 7,9-Dimethylpyrido[3′,2′ :4,5]thieno[3,2-d] pyrimidine-4(1H)-one

KW - DNA duplex stability of intercalating nucleic acids

KW - Intercalating nucleic acids

KW - Oligonucleotides with covalently bound intercalators

KW - Pyrene intercalators

UR - https://www.scopus.com/pages/publications/1542784471

U2 - 10.1081/NCN-120027829

DO - 10.1081/NCN-120027829

M3 - Article

C2 - 15043148

AN - SCOPUS:1542784471

SN - 1525-7770

VL - 23

SP - 207

EP - 225

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 1-2

ER -

Intercalating Nucleic Acids: The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities

Abstract

Keywords

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