Inflammatory diseases: Function of LncRNAs in their emergence and the role of mesenchymal stem cell secretome in their treatment

Muath Suliman; Sulieman Ibraheem Shelash Al-Hawary; F. Al-dolaimy; Ahmed Hjazi; Sami G. Almalki; Adnan Taan Alkhafaji; Ahmed Hussien Alawadi; Ali Alsaalamy; Sheela Bijlwan; Yasser Fakri Mustafa

doi:10.1016/j.prp.2023.154758

Inflammatory diseases: Function of LncRNAs in their emergence and the role of mesenchymal stem cell secretome in their treatment

Muath Suliman
, Sulieman Ibraheem Shelash Al-Hawary
, F. Al-dolaimy
, Ahmed Hjazi
, Sami G. Almalki
, Adnan Taan Alkhafaji
, Ahmed Hussien Alawadi
, Ali Alsaalamy
, Sheela Bijlwan
, Yasser Fakri Mustafa

Medical Laboratory Sciences

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

One of the best treatments for inflammatory diseases such as COVID−19, respiratory diseases and brain diseases is treatment with stem cells. Here we investigate the effect of stem cell therapy in the treatment of brain diseases.Preclinical studies have shown promising results, including improved functional recovery and tissue repair in animal models of neurodegenerative diseases, strokes,and traumatic brain injuries. However,ethical implications, safety concerns, and regulatory frameworks necessitate thorough evaluation before transitioning to clinical applications. Additionally, the complex nature of the brain and its intricate cellular environment present unique obstacles that must be overcome to ensure the successful integration and functionality of genetically engineered MSCs. The careful navigation of this path will determine whether the application of genetically engineered MSCs in brain tissue regeneration ultimately lives up to the hype surrounding it.

Original language	English
Article number	154758
Journal	Pathology Research and Practice
Volume	249
DOIs	https://doi.org/10.1016/j.prp.2023.154758
State	Published - Sep 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

MSCs
Neurological disorders
Regenerative medicine
Stem cell transplantation

Access to Document

10.1016/j.prp.2023.154758

Cite this

Suliman, M., Al-Hawary, S. I. S., Al-dolaimy, F., Hjazi, A., Almalki, S. G., Alkhafaji, A. T., Alawadi, A. H., Alsaalamy, A., Bijlwan, S., & Mustafa, Y. F. (2023). Inflammatory diseases: Function of LncRNAs in their emergence and the role of mesenchymal stem cell secretome in their treatment. Pathology Research and Practice, 249, Article 154758. https://doi.org/10.1016/j.prp.2023.154758

@article{9ee629be8d904d018d528a9f76858e4c,

title = "Inflammatory diseases: Function of LncRNAs in their emergence and the role of mesenchymal stem cell secretome in their treatment",

abstract = "One of the best treatments for inflammatory diseases such as COVID−19, respiratory diseases and brain diseases is treatment with stem cells. Here we investigate the effect of stem cell therapy in the treatment of brain diseases.Preclinical studies have shown promising results, including improved functional recovery and tissue repair in animal models of neurodegenerative diseases, strokes,and traumatic brain injuries. However,ethical implications, safety concerns, and regulatory frameworks necessitate thorough evaluation before transitioning to clinical applications. Additionally, the complex nature of the brain and its intricate cellular environment present unique obstacles that must be overcome to ensure the successful integration and functionality of genetically engineered MSCs. The careful navigation of this path will determine whether the application of genetically engineered MSCs in brain tissue regeneration ultimately lives up to the hype surrounding it.",

keywords = "MSCs, Neurological disorders, Regenerative medicine, Stem cell transplantation",

author = "Muath Suliman and Al-Hawary, \{Sulieman Ibraheem Shelash\} and F. Al-dolaimy and Ahmed Hjazi and Almalki, \{Sami G.\} and Alkhafaji, \{Adnan Taan\} and Alawadi, \{Ahmed Hussien\} and Ali Alsaalamy and Sheela Bijlwan and Mustafa, \{Yasser Fakri\}",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier GmbH",

year = "2023",

month = sep,

doi = "10.1016/j.prp.2023.154758",

language = "English",

volume = "249",

journal = "Pathology Research and Practice",

issn = "0344-0338",

publisher = "Elsevier GmbH",

}

TY - JOUR

T1 - Inflammatory diseases

T2 - Function of LncRNAs in their emergence and the role of mesenchymal stem cell secretome in their treatment

AU - Suliman, Muath

AU - Al-Hawary, Sulieman Ibraheem Shelash

AU - Al-dolaimy, F.

AU - Hjazi, Ahmed

AU - Almalki, Sami G.

AU - Alkhafaji, Adnan Taan

AU - Alawadi, Ahmed Hussien

AU - Alsaalamy, Ali

AU - Bijlwan, Sheela

AU - Mustafa, Yasser Fakri

PY - 2023/9

Y1 - 2023/9

N2 - One of the best treatments for inflammatory diseases such as COVID−19, respiratory diseases and brain diseases is treatment with stem cells. Here we investigate the effect of stem cell therapy in the treatment of brain diseases.Preclinical studies have shown promising results, including improved functional recovery and tissue repair in animal models of neurodegenerative diseases, strokes,and traumatic brain injuries. However,ethical implications, safety concerns, and regulatory frameworks necessitate thorough evaluation before transitioning to clinical applications. Additionally, the complex nature of the brain and its intricate cellular environment present unique obstacles that must be overcome to ensure the successful integration and functionality of genetically engineered MSCs. The careful navigation of this path will determine whether the application of genetically engineered MSCs in brain tissue regeneration ultimately lives up to the hype surrounding it.

AB - One of the best treatments for inflammatory diseases such as COVID−19, respiratory diseases and brain diseases is treatment with stem cells. Here we investigate the effect of stem cell therapy in the treatment of brain diseases.Preclinical studies have shown promising results, including improved functional recovery and tissue repair in animal models of neurodegenerative diseases, strokes,and traumatic brain injuries. However,ethical implications, safety concerns, and regulatory frameworks necessitate thorough evaluation before transitioning to clinical applications. Additionally, the complex nature of the brain and its intricate cellular environment present unique obstacles that must be overcome to ensure the successful integration and functionality of genetically engineered MSCs. The careful navigation of this path will determine whether the application of genetically engineered MSCs in brain tissue regeneration ultimately lives up to the hype surrounding it.

KW - MSCs

KW - Neurological disorders

KW - Regenerative medicine

KW - Stem cell transplantation

UR - https://www.scopus.com/pages/publications/85169548756

U2 - 10.1016/j.prp.2023.154758

DO - 10.1016/j.prp.2023.154758

M3 - Review article

C2 - 37660657

AN - SCOPUS:85169548756

SN - 0344-0338

VL - 249

JO - Pathology Research and Practice

JF - Pathology Research and Practice

M1 - 154758

ER -

Inflammatory diseases: Function of LncRNAs in their emergence and the role of mesenchymal stem cell secretome in their treatment

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this