TY - JOUR
T1 - In-vitro evaluation of some traditional medicinal plants on calcium oxalate urolithiasis
AU - Bar, Fatma M.Abdel
AU - Foudah, Ahmed I.
AU - Majrashi, Amjad J.
AU - Al-Dossery, Mariam F.
AU - Galala, Amal A.
N1 - Publisher Copyright:
© 2021, Emirates Journal of Food and Agriculture.All Rights Reserved.
PY - 2021
Y1 - 2021
N2 - The prevalence of urolithiasis in Middle East countries is predominantly high. Traditional medicinal plants play a role in the prevention and management of urolithiasis. The effect of Petroselinum crispum, rind of Citrus sinensis L., rind of Citrus limon L., Ammi visnaga (L.) LAM., Tamarindus indica L., Nigella sativa L., Cymbopogon proximus Hochst. ex A. Rich., Hibiscus sabdariffa L., Hordeum vulgare L., and Cymbopogon schoenanthus (L.) Spreng. on calcium oxalate crystallization was investigated in-vitro. The antispasmodic activity on acetylcholine-induced contraction in rat ileum was also screened ex-vivo. A significant reduction in the mean diagonal of calcium oxalate crystals was observed for P. crispum, C. proximus, N. sativa, and C. limon (4.41, 4.71, 5.44, and 5.67 μm, respectively) compared to the negative control (12.19 μm). H. sabdariffa exhibited antinucleation effect however, P. crispum showed a marked inhibition of calcium oxalate aggregation at 10 mg/mL after 60 min compared to the negative control. A remarkable ex-vivo antispasmodic activity was observed for C. proximus, C. schoenanthus, and A. visnaga extracts.
AB - The prevalence of urolithiasis in Middle East countries is predominantly high. Traditional medicinal plants play a role in the prevention and management of urolithiasis. The effect of Petroselinum crispum, rind of Citrus sinensis L., rind of Citrus limon L., Ammi visnaga (L.) LAM., Tamarindus indica L., Nigella sativa L., Cymbopogon proximus Hochst. ex A. Rich., Hibiscus sabdariffa L., Hordeum vulgare L., and Cymbopogon schoenanthus (L.) Spreng. on calcium oxalate crystallization was investigated in-vitro. The antispasmodic activity on acetylcholine-induced contraction in rat ileum was also screened ex-vivo. A significant reduction in the mean diagonal of calcium oxalate crystals was observed for P. crispum, C. proximus, N. sativa, and C. limon (4.41, 4.71, 5.44, and 5.67 μm, respectively) compared to the negative control (12.19 μm). H. sabdariffa exhibited antinucleation effect however, P. crispum showed a marked inhibition of calcium oxalate aggregation at 10 mg/mL after 60 min compared to the negative control. A remarkable ex-vivo antispasmodic activity was observed for C. proximus, C. schoenanthus, and A. visnaga extracts.
KW - Calcium oxalate aggregation
KW - Kidney stones
KW - Renal stone
KW - Traditional medicinal plants
KW - Urolithiasis
UR - https://www.scopus.com/pages/publications/85125532935
U2 - 10.9755/ejfa.2021.v33.i12.2792
DO - 10.9755/ejfa.2021.v33.i12.2792
M3 - Article
AN - SCOPUS:85125532935
SN - 2079-052X
VL - 33
SP - 1018
EP - 1027
JO - Emirates Journal of Food and Agriculture
JF - Emirates Journal of Food and Agriculture
IS - 12
ER -