In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide

Asmaa F. Kassem; Gaber O. Moustafa; Eman S. Nossier; Hemat S. Khalaf; Marwa M. Mounier; Suliman A. Al-Yousef; Sabry Y. Mahmoud

doi:10.1080/14756366.2019.1613390

In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N¹,N³-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide

Asmaa F. Kassem
, Gaber O. Moustafa
, Eman S. Nossier
, Hemat S. Khalaf
, Marwa M. Mounier
, Suliman A. Al-Yousef
, Sabry Y. Mahmoud

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

A series of N¹,N³-bis (1-oxopropan-2-yl) isophthalamide-based derivatives 4–16 were prepared and their structures were confirmed by different spectral tools. The cytotoxic potentiality of novel compounds 4–16 was assessed by the MTT assay method on colon, lung and breast tumour cell lines. Compound 5 gave the most significant specificity anticancer activity with safety response on normal cell lines. In vitro enzyme assay and several apoptotic parameters were examined to elucidate the mode of action of compound 5. Molecular docking studies also were simulated to put insight and give better understanding to its structural features.

Original language	English
Pages (from-to)	1247-1258
Number of pages	12
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	34
Issue number	1
DOIs	https://doi.org/10.1080/14756366.2019.1613390
State	Published - 1 Jan 2019
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

amino acids
anticancer activity
Isophthalamide
molecular docking
peptides

Access to Document

10.1080/14756366.2019.1613390

Cite this

Kassem, A. F., Moustafa, G. O., Nossier, E. S., Khalaf, H. S., Mounier, M. M., Al-Yousef, S. A., & Mahmoud, S. Y. (2019). In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N¹,N³-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide. Journal of Enzyme Inhibition and Medicinal Chemistry, 34(1), 1247-1258. https://doi.org/10.1080/14756366.2019.1613390

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title = "In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide",

abstract = "A series of N1,N3-bis (1-oxopropan-2-yl) isophthalamide-based derivatives 4–16 were prepared and their structures were confirmed by different spectral tools. The cytotoxic potentiality of novel compounds 4–16 was assessed by the MTT assay method on colon, lung and breast tumour cell lines. Compound 5 gave the most significant specificity anticancer activity with safety response on normal cell lines. In vitro enzyme assay and several apoptotic parameters were examined to elucidate the mode of action of compound 5. Molecular docking studies also were simulated to put insight and give better understanding to its structural features.",

keywords = "amino acids, anticancer activity, Isophthalamide, molecular docking, peptides",

author = "Kassem, \{Asmaa F.\} and Moustafa, \{Gaber O.\} and Nossier, \{Eman S.\} and Khalaf, \{Hemat S.\} and Mounier, \{Marwa M.\} and Al-Yousef, \{Suliman A.\} and Mahmoud, \{Sabry Y.\}",

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year = "2019",

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doi = "10.1080/14756366.2019.1613390",

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Kassem, AF, Moustafa, GO, Nossier, ES, Khalaf, HS, Mounier, MM, Al-Yousef, SA & Mahmoud, SY 2019, 'In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N¹,N³-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide', Journal of Enzyme Inhibition and Medicinal Chemistry, vol. 34, no. 1, pp. 1247-1258. https://doi.org/10.1080/14756366.2019.1613390

In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N¹,N³-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide. / Kassem, Asmaa F.; Moustafa, Gaber O.; Nossier, Eman S. et al.
In: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 34, No. 1, 01.01.2019, p. 1247-1258.

Research output: Contribution to journal › Article › peer-review

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