Histopathological Evaluation of Endometrial Curettage in Patients with Abnormal Uterine Bleeding: A Retrospective Study in Al Kharj City, Saudi Arabia

Background: One of the most common issues that adult females face is abnormal uterine bleeding (AUB). The preferred sampling method for identifying endometrial pathology is still uterine curettage or biopsy. Hormonal imbalance patterns, atrophic endometrium, endometritis, endometrial polyps, endometrial hyperplasia, and endometrial cancer are examples of common diseases. The purpose of this study was to identify the endometrial histological pattern in women of different ages who presented with AUB. Methods and Results: In this retrospective study, the medical records of 309 women who had endometrial curettage for AUB were reviewed. Every endometrial curettage specimen received for histological examination between January 2025 and June 2025 by the histopathology department of the Al Kharj Military Industries Corporation Hospital, in cooperation with the Department of Obstetrics and Gynecology, PSA Hospital, is included in the study. Endometrial biopsies were taken using a dilation and curettage (D&C) procedure. Following hematoxylin and eosin staining, a microscopic analysis was conducted. The most common histopathological finding was proliferative endometrial disorders (34.95%), followed by endometrial polyps (32.36%). Endometrial hyperplasia without atypia was found in 91 cases (29.45%). Endometrial adenocarcinoma was the sole diagnosis in four cases (1.29%). Conclusion: Abnormal uterine bleeding may be the only complaint presented by patients with endometrial lesions. Endometrial curettage and biopsy are reliable procedures for detecting endometrial pathology.(International Journal of Biomedicine. 2025;15(4):674-678.).