TY - JOUR
T1 - Hepatoprotective and antioxidant effects of methanol extractof Moringa oleifera leaves in rats
AU - Atta, Attia H.
AU - Soufy, Hamdy
AU - Nasr, Soad M.
AU - Soliman, Ahmed M.
AU - Nassar, Somia A.
AU - Maweri, Abduljalil Al
AU - Abd El-Aziz, Tamer H.
AU - Desouky, Hassan M.
AU - Abdalla, Aboelfetoh M.
PY - 2017
Y1 - 2017
N2 - Methanol extract of Moringa oleiferaleaveswas evaluated for its potential hepatoprotective and antioxidant effects in CCl4-intoxicated rats. Phytochemical analysis of methanol extract of M. oleifera leaves revealed the presence of high concentration of carbohydrate, cardiac glycosides, protein and amino acids with a moderate concentration of alkaloids, reducing sugar, saponins, phenols, flavonoids, fixed oil and fats.The GC- mass analysis of the methanol extract of M. oleifera leaves revealed the presence of 25 components. The major components were trans-2, 3-Dimethoxycinnamic acid ,Flavoxate, cis,cis-Muconic acid , Z-3,17-Octadecadien-1-ol acetate and Stevioside. Acute toxicity revealed no morbidity or mortality among rats receiving oral doses up to 4500 mg/kg.BW. M. oleifera leaves methanol extract normalized the hematological and biochemical parameters which have been deteriorated in CCl4-intoxicated rats. Moreover, the level of the antioxidant parameters in liver homogenate was also returned to normal levels. These results were confirmed by the improvement of the histopathological picture of the liver of treated rats. These results confirm the hepatoprotective and antioxidant effects of methanol extract of M. oleifera leaves.
AB - Methanol extract of Moringa oleiferaleaveswas evaluated for its potential hepatoprotective and antioxidant effects in CCl4-intoxicated rats. Phytochemical analysis of methanol extract of M. oleifera leaves revealed the presence of high concentration of carbohydrate, cardiac glycosides, protein and amino acids with a moderate concentration of alkaloids, reducing sugar, saponins, phenols, flavonoids, fixed oil and fats.The GC- mass analysis of the methanol extract of M. oleifera leaves revealed the presence of 25 components. The major components were trans-2, 3-Dimethoxycinnamic acid ,Flavoxate, cis,cis-Muconic acid , Z-3,17-Octadecadien-1-ol acetate and Stevioside. Acute toxicity revealed no morbidity or mortality among rats receiving oral doses up to 4500 mg/kg.BW. M. oleifera leaves methanol extract normalized the hematological and biochemical parameters which have been deteriorated in CCl4-intoxicated rats. Moreover, the level of the antioxidant parameters in liver homogenate was also returned to normal levels. These results were confirmed by the improvement of the histopathological picture of the liver of treated rats. These results confirm the hepatoprotective and antioxidant effects of methanol extract of M. oleifera leaves.
KW - Hepatoprotective
KW - LD50
KW - M. oleifera
KW - Phytochemical
UR - https://www.scopus.com/pages/publications/85020620561
M3 - Article
AN - SCOPUS:85020620561
SN - 1561-882X
VL - 24
SP - 249
EP - 268
JO - Wulfenia
JF - Wulfenia
IS - 3
ER -