Harnessing chitosan-adorned liposomes for enhanced drug delivery in cancer

Mohammad Arshad Javed Shaikh, Obaid Afzal, Waleed Hassan almalki, Imran Kazmi, Sami I. Alzarea, Mohammed Jafar, Abdulmalik Saleh Altamimi, Vikash Jakhmola, Krishnan Anand, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Cancer is a progressive disease that is caused by a combination of factors, including one's genetics, environment, and lifestyle choices. The pillars of cancer management include chemotherapy, surgical procedures, and radiation therapy; however, a wide variety of therapeutic combinations involving these and other therapies are also utilised. Despite its low success rate, chemotherapy remains the standard gold treatment. Drug carrier systems have been developed to address major challenges such as poor drug penetration and resistance. Future drug delivery systems should be based on chitosan liposomes because of their advantages, versatility, and ease of manufacture. In this article, we'll look at how liposomes based on chitosan can be used to treat several types of cancer through several different routes. Liposomes have been used in immunotherapy, and they can be engineered to respond to photothermal therapy as well as chemotherapeutic medicines and targeted agents.

Original languageEnglish
Article number104619
JournalJournal of Drug Delivery Science and Technology
Volume85
DOIs
StatePublished - Aug 2023

Keywords

  • Cancer
  • Chitosan
  • Drug delivery
  • Immunotherapy
  • Liposomes

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