Green, rapid and efficient synthesis of new antibacterial pyridopyrimidinone mediated by eutectic mixture of Urea/CuCl₂

An eco-friendly, efficient and green one-pot multicomponent preparation of pyridopyrimidine is reported. A mixture of urea/CuCl₂ was prepared and used as efficient catalyst to synthesize a various derivative of pyridopyrimidine with excellent yields in short times of reaction using microwave irradiation. All product were obtained with excellent yields (94-98%) in short time of reaction (few minutes). This green deep eutectic solvents was recycled and reutilized for many cycles without showing any significant loss of performance. The synthesized compounds were assessed for their activity against some bacterial strains. Therefore, just 6 compounds were showed active against the targeted bacterial strains.