Global sensitivity analysis implications on the design of PF-04475270 model predictive control system

In this study, we adopted Pharmacokinetic-Pharmacodynamic (PKPD) of Pfizer ophthalmic drug 5-{3-[(2S)-2-{(3R)-3-hydroxy-4-[3- (trifluoromethyl) phenyl] butyl}-5-oxopyrrolidin-1-yl] propyl} thiophene-2- carboxylate (PF-04475270) from literature and performed a series of global sensitivity analysis (GSA) to identify the most influential PKPD parameters of PF-04475270. We used the sensitivity analysis for everybody (SAFE) toolbox GSA with two different well-established GSA methods. Our GSA analyses successfully identified the aqueous chamber transfer rates as high-ranking parameters in the comparison with all the other 11 different model parameters. Our data with prioritised parameters suggest the need for probing the aqueous drug concentration for future design of model predictive control (MPC) release system of PF-04475270.