Fine‐Tuned DenseNet‐169 for Breast Cancer Metastasis Prediction Using FastAI and 1‐Cycle Policy

  • Adarsh Vulli
  • , Parvathaneni Naga Srinivasu
  • , Madipally Sai Krishna Sashank
  • , Jana Shafi
  • , Jaeyoung Choi
  • , Muhammad Fazal Ijaz

Research output: Contribution to journalArticlepeer-review

188 Scopus citations

Abstract

Lymph node metastasis in breast cancer may be accurately predicted using a DenseNet‐ 169 model. However, the current system for identifying metastases in a lymph node is manual and tedious. A pathologist well‐versed with the process of detection and characterization of lymph nodes goes through hours investigating histological slides. Furthermore, because of the massive size of most whole‐slide images (WSI), it is wise to divide a slide into batches of small image patches and apply methods independently on each patch. The present work introduces a novel method for the automated diagnosis and detection of metastases from whole slide images using the Fast AI framework and the 1‐cycle policy. Additionally, it compares this new approach to previous meth-ods. The proposed model has surpassed other state‐of‐art methods with more than 97.4% accuracy. In addition, a mobile application is developed for prompt and quick response. It collects user information and models to diagnose metastases present in the early stages of cancer. These results indi-cate that the suggested model may assist general practitioners in accurately analyzing breast cancer situations, hence preventing future complications and mortality. With digital image processing, histopathologic interpretation and diagnostic accuracy have improved considerably.

Original languageEnglish
Article number2988
JournalSensors
Volume22
Issue number8
DOIs
StatePublished - 1 Apr 2022
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • 1‐cycle policy
  • cancer
  • computational histopathology
  • DenseNet‐169
  • diagnostic odds ratio
  • FastAI
  • lymph nodes
  • whole‐slide images

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