TY - JOUR
T1 - Fabrication of letrozole formulation using chitosan nanoparticles through ionic gelation method
AU - Gomathi, Thandapani
AU - Sudha, P. N.
AU - Florence, J. Annie Kamala
AU - Venkatesan, Jayachandran
AU - Anil, Sukumaran
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/11
Y1 - 2017/11
N2 - In this study, the anticancer drug letrozole (LTZ) was formulated using chitosan nanoparticles (CS-NPs) with the crosslinking agent sodium tripolyphosphate (TPP). The nano-formulation was optimized by varying the concentration of drug. The prepared particles were characterized using FTIR, TGA, XRD, SEM, TEM and DLS. From the FTIR results, the appearance of a new peak for [dbnd]C–H, C[dbnd]C and C[dbnd]N confirms the formation of LTZ loaded chitosan nanoparticles. TEM images shows that the average particle size was in the range of 60–80 nm and 20–40 mm air dried and freeze dried samples respectively. Also the prepared formulation had been evaluated in vitro for determining its hemocompatability, biodegradability and serum stability. The preliminary studies supported that the chitosan nanoparticles formulation has biocompatibility and hemocompatible properties and it can act as an effective pharmaceutical excipient for letrozole.
AB - In this study, the anticancer drug letrozole (LTZ) was formulated using chitosan nanoparticles (CS-NPs) with the crosslinking agent sodium tripolyphosphate (TPP). The nano-formulation was optimized by varying the concentration of drug. The prepared particles were characterized using FTIR, TGA, XRD, SEM, TEM and DLS. From the FTIR results, the appearance of a new peak for [dbnd]C–H, C[dbnd]C and C[dbnd]N confirms the formation of LTZ loaded chitosan nanoparticles. TEM images shows that the average particle size was in the range of 60–80 nm and 20–40 mm air dried and freeze dried samples respectively. Also the prepared formulation had been evaluated in vitro for determining its hemocompatability, biodegradability and serum stability. The preliminary studies supported that the chitosan nanoparticles formulation has biocompatibility and hemocompatible properties and it can act as an effective pharmaceutical excipient for letrozole.
KW - Chitosan nanoparticles
KW - Hemocompatability
KW - Letrozole
KW - Optimization
KW - Serum stability
UR - https://www.scopus.com/pages/publications/85011958931
U2 - 10.1016/j.ijbiomac.2017.01.147
DO - 10.1016/j.ijbiomac.2017.01.147
M3 - Article
C2 - 28185930
AN - SCOPUS:85011958931
SN - 0141-8130
VL - 104
SP - 1820
EP - 1832
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
ER -
