Fabrication of curcumin‑incorporated poly glycerol sebacate/poly lactide acid (PGS/PLA) hydrogel to enhance full‑thickness wound healing in diabetic rats

New wound dressings with therapeutic benefits are consistently being developed to enhance the wound healing process. In present study, a biocompatible wound dressing was fabricated using curcumin- incorporated poly glycerol sebacate/poly lactide acid (PGS/PLA) hydrogel to promote diabetic wound healing in rats. A total of 60 diabetic rats were randomly planned to four groups: the control group, PGS/PLA group, curcumin group, and PGS/PLA+Curcumin group. Sampling occurred on days 7 and 14 for further evaluations. Our findings revealed that the rates of wound healing, dimensions and thickness of newly created epidermis, counts of blood vessels, collagen accumulation, levels of TGF-β and VEGF cytokines, and wound robustness were notably greater in the treated groups versus the control group, with these effects being more significant in the PGS/PLA+Curcumin group. In contrast to the other groups, the PGS/PLA+Curcumin group exhibited a more significant reduction in the inflammatory and apoptotic cell counts, and concentration levels of IL-1β and TNF-α cytokines. In conclusion, it was established that the partnership of PGS/PLA and curcumin greatly improves healing of diabetic wounds.