TY - JOUR
T1 - Expression of cyclooxygenase-2 (COX-2) in colorectal adenocarcinoma
T2 - An immunohistochemical and histopathological study
AU - Mahmoud, Abla Sayed
AU - Umair, Ayesha
AU - Azzeghaiby, Saleh Nasser
AU - Alqahtani, Fahad Hussain
AU - Hanouneh, Salah
AU - Tarakji, Bassel
PY - 2014
Y1 - 2014
N2 - Background: The aim of this study was to evaluate cyclooxygenase-2 (COX-2) immunoreactivity in colorectal adenocarcinomas and to find correlations with different pathological features. Materials and Methods: This study included 35 cases of colorectal carcinoma foir which surgical colectomy specimens were collected. Immunohistochemical staining of COX-2 (cyclooxygenase-2) is done by using the Streptavidin-biotin technique. Results: This work reveals that COX-2 is positive in most cases of colorectal carcinoma and negative in normal colon tissue with statistically non significant relations between COX-2 immunostaining and different pathological features. Conclusions: Our data suggest over expression of COX-2 protein in colorectal carcinoma in contrast to normal mucosa, with a possible role in cell proliferation in carcinogenesis.
AB - Background: The aim of this study was to evaluate cyclooxygenase-2 (COX-2) immunoreactivity in colorectal adenocarcinomas and to find correlations with different pathological features. Materials and Methods: This study included 35 cases of colorectal carcinoma foir which surgical colectomy specimens were collected. Immunohistochemical staining of COX-2 (cyclooxygenase-2) is done by using the Streptavidin-biotin technique. Results: This work reveals that COX-2 is positive in most cases of colorectal carcinoma and negative in normal colon tissue with statistically non significant relations between COX-2 immunostaining and different pathological features. Conclusions: Our data suggest over expression of COX-2 protein in colorectal carcinoma in contrast to normal mucosa, with a possible role in cell proliferation in carcinogenesis.
KW - Antibodies
KW - Colorectal adenocarcinoma
KW - COX-2
KW - Immunohistochemistry
UR - http://www.scopus.com/inward/record.url?scp=84929156324&partnerID=8YFLogxK
U2 - 10.7314/APJCP.2014.15.16.6787
DO - 10.7314/APJCP.2014.15.16.6787
M3 - Article
C2 - 25169526
AN - SCOPUS:84929156324
SN - 1513-7368
VL - 15
SP - 6787
EP - 6790
JO - Asian Pacific Journal of Cancer Prevention
JF - Asian Pacific Journal of Cancer Prevention
IS - 16
ER -
