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Exploring the detailed role of interleukins in cancer: A comprehensive review of literature

  • Raed Obaid Saleh
  • , Saade Abdalkareem Jasim
  • , Wesam R. Kadhum
  • , Ahmed Hjazi
  • , Ali Faraz
  • , Mohammed Kadhem Abid
  • , Alexey Yumashev
  • , Ahmed Alawadi
  • , Ibrahim Ahmed Zaki Aiad
  • , Ali Alsalamy

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

The cancer cells that are not normal can grow into tumors, invade surrounding tissues, and travel to other parts of the body via the lymphatic or circulatory systems. Interleukins, a vital class of signaling proteins, facilitate cell-to-cell contact within the immune system. A type of non-coding RNA known as lncRNAs mediates its actions by regulating miRNA-mRNA roles (Interleukins). Because of their dual function in controlling the growth of tumors and altering the immune system's response to cancer cells, interleukins have been extensively studied concerning cancer. Understanding the complex relationships between interleukins, the immune system, the tumor microenvironment, and the components of interleukin signaling pathways that impact the miRNA-mRNA axis, including lncRNAs, has advanced significantly in cancer research. Due to the significant and all-encompassing influence of interleukins on the immune system and the development and advancement of cancers, lncRNAs play a crucial role in cancer research by modulating interleukins. Their diverse effects on immune system regulation, tumor growth encouragement, and tumor inhibition make them appealing candidates for potential cancer treatments and diagnostics. A deeper understanding of the relationship between the biology of interleukin and lncRNAs will likely result in more effective immunotherapy strategies and individualized cancer treatments.

Original languageEnglish
Article number155284
JournalPathology Research and Practice
Volume257
DOIs
StatePublished - May 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Cancer
  • ICIs
  • Interleukins
  • LncRNAs

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