Exploring marine-derived bioactive compounds for dual inhibition of Pseudomonas aeruginosa LpxA and LpxD: integrated bioinformatics and cheminformatics approaches

Biochemistry, Genetics and Molecular Biology

• Pseudomonas aeruginosa 100%
• Biosynthesis 50%
• Lipid A 50%
• Anabolism 25%
• Uridine Diphosphate 25%
• Small Molecule 25%
• Nucleophilicity 25%
• Uridine Diphosphate N-Acetylglucosamine 25%
• Electrophilicity 25%
• Lipopolysaccharide 25%
• Lipid 25%

Chemistry

• Oscillatoxin A 100%
• Lipid A 66%
• Lipopolysaccharide 33%
• Donor 33%
• N-Acetylglucosamine 33%
• UDP(3-) 33%
• Uridine 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Lipid A 50%
• Antibiotic Agent 25%
• Uridine Diphosphate N Acetylglucosamine 25%
• Uridine Diphosphate 25%
• Lipopolysaccharide 25%