TY - JOUR
T1 - Enhancement in structure and cell viability of graphene oxide modified copper oxide/hematite composite filled chitosan film for medical applications
AU - Elabbasy, Mohamed Tharwat
AU - Fathuldeen, Anas Abdulqader
AU - Othman, Mohamed S.
AU - Abdelfattah Ahmed, Mai Ali
AU - El-Morsy, M. A.
AU - Menazea, A. A.
N1 - Publisher Copyright:
© 2025 Elsevier Ltd and Techna Group S.r.l. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
PY - 2026/1
Y1 - 2026/1
N2 - As a result of their biocompatibility and origin from a naturally renewable and biodegradable source, chitosan-based wound dressings are employed in this case. In this study, integrated chitosan (CS) films with iron oxide, cuprous oxide, and graphene oxide are investigated for their structural, thermal, morphological, biological, and optical properties. The functional group analysis of FTIR spectroscopy was applied to introduce the bond formation of the CS-based films. The resulting EDX information also supports the high oxygenation and purity of Fe2O3/CuO/GO@CS. SEM micrograph of Fe2O3/CuO/GO@CS porous film reveals a highly rough surface with a relatively high surface area due to the existence of GO sheets. Besides, CuO grains accumulation plays a crucial role in thermal behavior in that it reduces the emission of volatile molecules after decomposition. Regarding the wettability of Fe2O3/CuO/GO@CS, it occupies the second lowest angle with 57.55 ± 5.75°. The NCs show shrinkage in the direct band gap (2.25–2.35 e.V) in comparison with pure chitosan. The Fe2O3/CuO/GO@CS film's cytotoxicity toward the human lung cell line is discussed here. The cell viability of using 3.7 μg/ml is observed to be 97.54%, while 29.3 μg/ml results in 79.74%. The use of 7500 μg/ml results in viability percentages of 10.7%. The results demonstrated the promising behavior of the CS based films in wound healing.
AB - As a result of their biocompatibility and origin from a naturally renewable and biodegradable source, chitosan-based wound dressings are employed in this case. In this study, integrated chitosan (CS) films with iron oxide, cuprous oxide, and graphene oxide are investigated for their structural, thermal, morphological, biological, and optical properties. The functional group analysis of FTIR spectroscopy was applied to introduce the bond formation of the CS-based films. The resulting EDX information also supports the high oxygenation and purity of Fe2O3/CuO/GO@CS. SEM micrograph of Fe2O3/CuO/GO@CS porous film reveals a highly rough surface with a relatively high surface area due to the existence of GO sheets. Besides, CuO grains accumulation plays a crucial role in thermal behavior in that it reduces the emission of volatile molecules after decomposition. Regarding the wettability of Fe2O3/CuO/GO@CS, it occupies the second lowest angle with 57.55 ± 5.75°. The NCs show shrinkage in the direct band gap (2.25–2.35 e.V) in comparison with pure chitosan. The Fe2O3/CuO/GO@CS film's cytotoxicity toward the human lung cell line is discussed here. The cell viability of using 3.7 μg/ml is observed to be 97.54%, while 29.3 μg/ml results in 79.74%. The use of 7500 μg/ml results in viability percentages of 10.7%. The results demonstrated the promising behavior of the CS based films in wound healing.
KW - Chitosan
KW - CuO
KW - FeO
KW - Graphene oxide
KW - Wound healing
UR - https://www.scopus.com/pages/publications/105025763607
U2 - 10.1016/j.ceramint.2025.11.379
DO - 10.1016/j.ceramint.2025.11.379
M3 - Article
AN - SCOPUS:105025763607
SN - 0272-8842
VL - 52
SP - 792
EP - 802
JO - Ceramics International
JF - Ceramics International
IS - 1
ER -