Electrochemical sensing of antibiotic drug amoxicillin in the presence of dopamine at simple and selective carbon paste electrode activated with cetyltrimethylammonium bromide surfactant

The effective, selective, and electrochemically steady cetyltrimethylammonium bromide drop-casted carbon paste electrode was constructed for the detection of amoxicillin in presence of dopamine through cyclic voltammetry method. The modified and unmodified electrode materials were characterized by various methods like field emission scanning electron microscopy, cyclic voltammetry, and electrochemical impedance spectroscopy with acceptable results. The constructed modified sensor delivers a higher electrocatalytic nature for the oxidation of 0.1 mM amoxicillin in 0.1 M phosphate buffer saline of 6.5 pH with high peak current and lower peak potential than the bare carbon paste electrode. The analytical applicability of modified electrode for amoxicillin electro-oxidation was detected by increasing the amoxicillin concentration in the range from 10 to 150 µM with fine limit of detection and the limit of quantification of 5.90 µM and 19.67 µM, respectively. This article discloses a facile and recommended approach for the concurrent inspection of amoxicillin in the presence of dopamine. The modified sensor gives high stability, repeatability, reproducibility, and sensitivity. The premeditated method and modified sensor give a fine recovery for amoxicillin detection in medication sample. Graphical abstract: [Figure not available: see fulltext.]