Efficient Synthesis of Various Substituted (Thio)Ureas, Semicarbazides, Thiosemicarbazides, Thiazolidones, and Oxadiazole Derived from [2.2]Paracyclophane

Mohammed B. Alshammari, Ashraf A. Aly, Stefan Bräse, Martin Nieger, Lamiaa E. Abd El-Haleem

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Abstract

The strategies of the syntheses of various (thio)ureas, semicarbazides, thiosemicarbazides, thiazolidones, and oxadiazole derived from the [2.2]paracyclophane molecule are achieved starting with 4-(2.2]paracyclophanyl)isocyanate. The structures of the obtained products were elucidated by NMR, mass spectrometry, and infrared (IR) spectroscopy in addition to high-resolution mass spectrometry (HRMS). X-ray structure analysis was also used to prove the assigned structure.

Original languageEnglish
Pages (from-to)12879-12890
Number of pages12
JournalACS Omega
Volume7
Issue number15
DOIs
StatePublished - 19 Apr 2022

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