Efficient novel eutectic-mixture-mediated synthesis of benzoxazole-linked pyrrolidin-2-one heterocycles

Yassine Riadi; Oussama Ouerghi; Mohammed H. Geesi; Abdellah Kaiba; El Hassane Anouar; Philippe Guionneau

doi:10.1016/j.molliq.2020.115011

Efficient novel eutectic-mixture-mediated synthesis of benzoxazole-linked pyrrolidin-2-one heterocycles

Yassine Riadi, Oussama Ouerghi, Mohammed H. Geesi, Abdellah Kaiba, El Hassane Anouar, Philippe Guionneau

Université de Bordeaux

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

In this study, new benzoxazole-linked pyrrolidinone heterocyclic compounds were synthesized by an eco-efficient strategy using substituted benzylamines and 2-aminophenol under ultrasonic irradiation in the presence of a newly designed metal-free deep eutectic solvent (DES). This DES was prepared by using a eutectic mixture of urea and a synthesized glycine-derived ionic liquid. X-ray diffraction and infrared spectroscopy were employed to investigate the structure of the ionic liquid and characterize the DES, respectively. This method exhibited key advantages of high productivity, a short reaction time, and simple processing. Moreover, this DES was easily separated from reaction mixtures and can be recycled for multiple reactions.

Original language	English
Article number	115011
Journal	Journal of Molecular Liquids
Volume	323
DOIs	https://doi.org/10.1016/j.molliq.2020.115011
State	Published - 1 Feb 2021

Keywords

Benzoxazole moiety
Eutectic mixture
Glycine derivative
Ionic liquid
Pyrrolidinone

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10.1016/j.molliq.2020.115011

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title = "Efficient novel eutectic-mixture-mediated synthesis of benzoxazole-linked pyrrolidin-2-one heterocycles",

abstract = "In this study, new benzoxazole-linked pyrrolidinone heterocyclic compounds were synthesized by an eco-efficient strategy using substituted benzylamines and 2-aminophenol under ultrasonic irradiation in the presence of a newly designed metal-free deep eutectic solvent (DES). This DES was prepared by using a eutectic mixture of urea and a synthesized glycine-derived ionic liquid. X-ray diffraction and infrared spectroscopy were employed to investigate the structure of the ionic liquid and characterize the DES, respectively. This method exhibited key advantages of high productivity, a short reaction time, and simple processing. Moreover, this DES was easily separated from reaction mixtures and can be recycled for multiple reactions.",

keywords = "Benzoxazole moiety, Eutectic mixture, Glycine derivative, Ionic liquid, Pyrrolidinone",

author = "Yassine Riadi and Oussama Ouerghi and Geesi, \{Mohammed H.\} and Abdellah Kaiba and Anouar, \{El Hassane\} and Philippe Guionneau",

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doi = "10.1016/j.molliq.2020.115011",

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T1 - Efficient novel eutectic-mixture-mediated synthesis of benzoxazole-linked pyrrolidin-2-one heterocycles

AU - Riadi, Yassine

AU - Ouerghi, Oussama

AU - Geesi, Mohammed H.

AU - Kaiba, Abdellah

AU - Anouar, El Hassane

AU - Guionneau, Philippe

PY - 2021/2/1

Y1 - 2021/2/1

N2 - In this study, new benzoxazole-linked pyrrolidinone heterocyclic compounds were synthesized by an eco-efficient strategy using substituted benzylamines and 2-aminophenol under ultrasonic irradiation in the presence of a newly designed metal-free deep eutectic solvent (DES). This DES was prepared by using a eutectic mixture of urea and a synthesized glycine-derived ionic liquid. X-ray diffraction and infrared spectroscopy were employed to investigate the structure of the ionic liquid and characterize the DES, respectively. This method exhibited key advantages of high productivity, a short reaction time, and simple processing. Moreover, this DES was easily separated from reaction mixtures and can be recycled for multiple reactions.

AB - In this study, new benzoxazole-linked pyrrolidinone heterocyclic compounds were synthesized by an eco-efficient strategy using substituted benzylamines and 2-aminophenol under ultrasonic irradiation in the presence of a newly designed metal-free deep eutectic solvent (DES). This DES was prepared by using a eutectic mixture of urea and a synthesized glycine-derived ionic liquid. X-ray diffraction and infrared spectroscopy were employed to investigate the structure of the ionic liquid and characterize the DES, respectively. This method exhibited key advantages of high productivity, a short reaction time, and simple processing. Moreover, this DES was easily separated from reaction mixtures and can be recycled for multiple reactions.

KW - Benzoxazole moiety

KW - Eutectic mixture

KW - Glycine derivative

KW - Ionic liquid

KW - Pyrrolidinone

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DO - 10.1016/j.molliq.2020.115011

M3 - Article

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JO - Journal of Molecular Liquids

JF - Journal of Molecular Liquids

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ER -

Efficient novel eutectic-mixture-mediated synthesis of benzoxazole-linked pyrrolidin-2-one heterocycles

Abstract

Keywords

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