Dynamical behavior of tumor-immune system with fractal-fractional operator

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Abstract

In this paper, the dynamical behavior of the fractional-order cancer model has been analyzed with the fractal-fractional operator, which discretized the conformable cancer model. The fractional-order model consists of the system of nonlinear fractional differential equations. Also, we discuss the fractional-order model to check the relationship between the immune system and cancer cells by mixing IL-12 cytokine and anti-PD-L1 inhibitor. The tumor-immune model has been studied qualitatively as well as quantitatively via Atangana-Baleanu fractal-fractional operator. The nonlinear analysis is used to check the Ulam-Hyres stability of the proposed model. Moreover, the dynamical behavior for the fractional-order model has been checked by using a fractal-fractional operator with a generalized Mittag-Leffler Kernel and verifying the effect of fractional parameters. Finally, the obtained solutions are interpreted biologically, and simulations are carried out to illustrate cancer disease and support theoretical results, which will be helpful for further analysis and to control the effect of cancer in the community.

Original languageEnglish
Pages (from-to)8751-8773
Number of pages23
JournalAIMS Mathematics
Volume7
Issue number5
DOIs
StatePublished - 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • Anti-PD-L1 inhibitor
  • Existence-uniqueness
  • Fractional operator
  • IL-12 cytokin
  • Mittag-Leffler kernel
  • Tumor-immune model
  • Ulam-Hyres stability

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