Abstract
In the present study, solubilities of atenolol in seven different pure solvents namely water, ethanol, ethylacetate, dichloromethane, dioxane, poly(ethylene glycol)-400 (PEG-400) and propylene glycol (PG) at temperature from (298.15 to 318.15) K were performed using the shake flask method. Experimentally determined solubilities of atenolol were regressed by using Apelblat equation with root mean square deviations in the range of 0.29-2.59% in all pure solvents. However, the correlation coefficients were in the range of 0.996-0.998 all solvents investigated. The mole fraction solubility was observed highest in PEG- 400 solvent due to its highest molar mass (400 g/mol) compared to other solvents used in the study. The data generated in this study could be useful for researchers involved in formulation and development of atenolol products.
| Original language | English |
|---|---|
| Pages (from-to) | 1571-1575 |
| Number of pages | 5 |
| Journal | Latin American Journal of Pharmacy |
| Volume | 34 |
| Issue number | 8 |
| State | Published - 26 Sep 2015 |
Keywords
- Apelblat equation
- Atenolol thermodynamics and solubility
- Dissolution
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