Design, synthesis and antimicrobial evaluation of novel carbendazim dithioate analogs

A novel series of carbendazim dithioate analogs was synthesized by the reaction of 2-aminobenzimdazole with CS2 and different alkyl halide in one pot reaction. All the chemical structure of carbendazim analogs were elucidated with all the spectroscopical tools IR, ¹H, ¹³C NMR and mass-spectroscopy. All the synthesized carbendazim analogs were screened for their in vitro antimicrobial activity against different Gram-positive (Staphylococcus aureus and Micrococcus luteus), Gram-negative (Escherichia coli and Klebsiella pneumonia) bacteria, fungi (Fusarium solani and Fusarium oxysporu) and in vivo against soil dehydrogenase activity. Among the carbendazim dithioates, some analogs were the most effective analogs against all the Gram-negative and positive-bacteria. While the most of them showed slight activities against Fusarium solani and Fusarium oxysporum. One of these analogs seemed to be more suppressive for dehydrogenase activity of soil microorganisms compared to all carbendazim sulfur analogs.