Design and optimization of pregabalin conventional release formulations using central composite design and response surface methodology

The aim of the current investigation was to formulate a cost-effective and simple pregabalin oral tablet formulation by direct compression method. Fifteen different trial formulations were prepared using central composite design (CCD) with response surface methodology (RSM) to obtain the best optimize formulation. Three variables with five different levels (-1.73,-1, 0, +1, and +1.73) were used to develop and optimize pregabalin tablets. All formulations were evaluated utilizing micromeritic studies along with standard physicochemical tests. After initial testing, four best-selected formulations were subjected to stability studies. Results of micromeritics testing of powder blend and various physicochemical tests were found within acceptable USP limits. The drug released pattern of four best formulations was followed the first-order kinetics. Formulations tests for stability studies showed no physical and chemical changes even after storage under accelerated conditions. It is concluded that pregabalin immediate release tablets were successfully prepared by direct compression method using CCD and RSM techniques.