D-Dimer Level Among COVID-19 Patients as Biological Mediator for Hyper Coagulation State

Shahd Adil Mohammed Omer; Elharam Ibrahim Abdallah; Abdel Rahim Mahmoud Muddathir; Alaa Eltayeb Omer; Lienda Bashier Eltayeb

doi:10.3923/pjbs.2022.569.574

D-Dimer Level Among COVID-19 Patients as Biological Mediator for Hyper Coagulation State

Shahd Adil Mohammed Omer, Elharam Ibrahim Abdallah, Abdel Rahim Mahmoud Muddathir, Alaa Eltayeb Omer, Lienda Bashier Eltayeb

Medical Laboratory Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Objective: Viremia due to SARS-CoV-2 lead variety of biochemical change in the human body, which play a crucial role in the activation of the coagulation cascade causing thrombotic complications and coagulopathies. The study aimed to ascertain the D-dimer level as a biological mediator in COVID-19 patients in Khartoum state and compare the results to the control group. Materials and Methods: A cross-sectional study was conducted during the period of August to December, 2021, including 50 healthy patients and 50 COVID-19 patients, blood samples were collected from study groups for measurement of D-dimer level using an I Chroma device. Statistical analysis was conducted using SSPS version 21. Results: This study revealed a statistically increased D-dimer level among COVID-19 patients compared with the control group (2000-10000 vs. up to 500 ng mLG¹), respectively. Conclusion: Viremia induced by COVID-19 infection can cause a high D-dimer level which can lead to thrombosis event or bleeding tendency.

Original language	English
Pages (from-to)	569-574
Number of pages	6
Journal	Pakistan Journal of Biological Sciences
Volume	25
Issue number	6
DOIs	https://doi.org/10.3923/pjbs.2022.569.574
State	Published - 2022

Keywords

coagulation cascade
D-dimer
hyper coagulopathy
SARS-CoV-2
thromboembolism
thrombosis
viremia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3923/pjbs.2022.569.574

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title = "D-Dimer Level Among COVID-19 Patients as Biological Mediator for Hyper Coagulation State",

abstract = "Background and Objective: Viremia due to SARS-CoV-2 lead variety of biochemical change in the human body, which play a crucial role in the activation of the coagulation cascade causing thrombotic complications and coagulopathies. The study aimed to ascertain the D-dimer level as a biological mediator in COVID-19 patients in Khartoum state and compare the results to the control group. Materials and Methods: A cross-sectional study was conducted during the period of August to December, 2021, including 50 healthy patients and 50 COVID-19 patients, blood samples were collected from study groups for measurement of D-dimer level using an I Chroma device. Statistical analysis was conducted using SSPS version 21. Results: This study revealed a statistically increased D-dimer level among COVID-19 patients compared with the control group (2000-10000 vs. up to 500 ng mLG1), respectively. Conclusion: Viremia induced by COVID-19 infection can cause a high D-dimer level which can lead to thrombosis event or bleeding tendency.",

keywords = "coagulation cascade, D-dimer, hyper coagulopathy, SARS-CoV-2, thromboembolism, thrombosis, viremia",

author = "Omer, \{Shahd Adil Mohammed\} and Abdallah, \{Elharam Ibrahim\} and Muddathir, \{Abdel Rahim Mahmoud\} and Omer, \{Alaa Eltayeb\} and Eltayeb, \{Lienda Bashier\}",

note = "Publisher Copyright: {\textcopyright} 2022 Shahd Adil Mohammed Omer et al.",

year = "2022",

doi = "10.3923/pjbs.2022.569.574",

language = "English",

volume = "25",

pages = "569--574",

journal = "Pakistan Journal of Biological Sciences",

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number = "6",

}

TY - JOUR

T1 - D-Dimer Level Among COVID-19 Patients as Biological Mediator for Hyper Coagulation State

AU - Omer, Shahd Adil Mohammed

AU - Abdallah, Elharam Ibrahim

AU - Muddathir, Abdel Rahim Mahmoud

AU - Omer, Alaa Eltayeb

AU - Eltayeb, Lienda Bashier

PY - 2022

Y1 - 2022

N2 - Background and Objective: Viremia due to SARS-CoV-2 lead variety of biochemical change in the human body, which play a crucial role in the activation of the coagulation cascade causing thrombotic complications and coagulopathies. The study aimed to ascertain the D-dimer level as a biological mediator in COVID-19 patients in Khartoum state and compare the results to the control group. Materials and Methods: A cross-sectional study was conducted during the period of August to December, 2021, including 50 healthy patients and 50 COVID-19 patients, blood samples were collected from study groups for measurement of D-dimer level using an I Chroma device. Statistical analysis was conducted using SSPS version 21. Results: This study revealed a statistically increased D-dimer level among COVID-19 patients compared with the control group (2000-10000 vs. up to 500 ng mLG1), respectively. Conclusion: Viremia induced by COVID-19 infection can cause a high D-dimer level which can lead to thrombosis event or bleeding tendency.

AB - Background and Objective: Viremia due to SARS-CoV-2 lead variety of biochemical change in the human body, which play a crucial role in the activation of the coagulation cascade causing thrombotic complications and coagulopathies. The study aimed to ascertain the D-dimer level as a biological mediator in COVID-19 patients in Khartoum state and compare the results to the control group. Materials and Methods: A cross-sectional study was conducted during the period of August to December, 2021, including 50 healthy patients and 50 COVID-19 patients, blood samples were collected from study groups for measurement of D-dimer level using an I Chroma device. Statistical analysis was conducted using SSPS version 21. Results: This study revealed a statistically increased D-dimer level among COVID-19 patients compared with the control group (2000-10000 vs. up to 500 ng mLG1), respectively. Conclusion: Viremia induced by COVID-19 infection can cause a high D-dimer level which can lead to thrombosis event or bleeding tendency.

KW - coagulation cascade

KW - D-dimer

KW - hyper coagulopathy

KW - SARS-CoV-2

KW - thromboembolism

KW - thrombosis

KW - viremia

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U2 - 10.3923/pjbs.2022.569.574

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AN - SCOPUS:85134628127

SN - 1028-8880

VL - 25

SP - 569

EP - 574

JO - Pakistan Journal of Biological Sciences

JF - Pakistan Journal of Biological Sciences

IS - 6

ER -

D-Dimer Level Among COVID-19 Patients as Biological Mediator for Hyper Coagulation State

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Keywords

UN SDGs

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