Cytotoxic constituents of Alocasia macrorrhiza

Marwa Elsbaey; Kadria F.M. Ahmed; Mahmoud F. Elsebai; Ahmed Zaghloul; Mohamed M.A. Amer; Mohamed Farid I. Lahloub

doi:10.1515/znc-2015-0157

Cytotoxic constituents of Alocasia macrorrhiza

Marwa Elsbaey
, Kadria F.M. Ahmed
, Mahmoud F. Elsebai
, Ahmed Zaghloul
, Mohamed M.A. Amer
, Mohamed Farid I. Lahloub

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

An indole alkaloid, 2-(5-hydroxy-1H-indol-3-yl)-2-oxo-acetic acid (1) isolated for the first time from nature, in addition to the nine known compounds 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (2), alocasin B (3), hyrtiosin B (4), α-monopalmitin (5), 1-O-β-D-glucopyranosyl-(2S, 3R, 4E, 8Z)-2-[(2(R)-hydroctadecanoyl) amido]-4,8-octadecadiene-1,3-diol (6), 3-epi-betulinic acid (7), 3-epi-ursolic acid (8), β-sitosterol (9) and β-sitosterol 3-O-β-D-glucoside (10) were isolated from the rhizomes of Alocasia macrorrhiza (Araceae). Their structures were elucidated by 1D and 2D NMR spectroscopic data. Of these compounds, 6 exhibited the strongest cytotoxicity against the four tested human cancer cell lines (IC₅₀ of about 10 μM against Hep-2 larynx cancer cells).

Original language	English
Pages (from-to)	21-25
Number of pages	5
Journal	Zeitschrift fur Naturforschung - Section C Journal of Biosciences
Volume	72
Issue number	1-2
DOIs	https://doi.org/10.1515/znc-2015-0157
State	Published - 1 Jan 2017
Externally published	Yes

Keywords

Alocasia macrorrhiza
epi-triterpene
indole alkaloids

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1515/znc-2015-0157

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title = "Cytotoxic constituents of Alocasia macrorrhiza",

abstract = "An indole alkaloid, 2-(5-hydroxy-1H-indol-3-yl)-2-oxo-acetic acid (1) isolated for the first time from nature, in addition to the nine known compounds 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (2), alocasin B (3), hyrtiosin B (4), α-monopalmitin (5), 1-O-β-D-glucopyranosyl-(2S, 3R, 4E, 8Z)-2-[(2(R)-hydroctadecanoyl) amido]-4,8-octadecadiene-1,3-diol (6), 3-epi-betulinic acid (7), 3-epi-ursolic acid (8), β-sitosterol (9) and β-sitosterol 3-O-β-D-glucoside (10) were isolated from the rhizomes of Alocasia macrorrhiza (Araceae). Their structures were elucidated by 1D and 2D NMR spectroscopic data. Of these compounds, 6 exhibited the strongest cytotoxicity against the four tested human cancer cell lines (IC50 of about 10 μM against Hep-2 larynx cancer cells).",

keywords = "Alocasia macrorrhiza, epi-triterpene, indole alkaloids",

author = "Marwa Elsbaey and Ahmed, \{Kadria F.M.\} and Elsebai, \{Mahmoud F.\} and Ahmed Zaghloul and Amer, \{Mohamed M.A.\} and Lahloub, \{Mohamed Farid I.\}",

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doi = "10.1515/znc-2015-0157",

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T1 - Cytotoxic constituents of Alocasia macrorrhiza

AU - Elsbaey, Marwa

AU - Ahmed, Kadria F.M.

AU - Elsebai, Mahmoud F.

AU - Zaghloul, Ahmed

AU - Amer, Mohamed M.A.

AU - Lahloub, Mohamed Farid I.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - An indole alkaloid, 2-(5-hydroxy-1H-indol-3-yl)-2-oxo-acetic acid (1) isolated for the first time from nature, in addition to the nine known compounds 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (2), alocasin B (3), hyrtiosin B (4), α-monopalmitin (5), 1-O-β-D-glucopyranosyl-(2S, 3R, 4E, 8Z)-2-[(2(R)-hydroctadecanoyl) amido]-4,8-octadecadiene-1,3-diol (6), 3-epi-betulinic acid (7), 3-epi-ursolic acid (8), β-sitosterol (9) and β-sitosterol 3-O-β-D-glucoside (10) were isolated from the rhizomes of Alocasia macrorrhiza (Araceae). Their structures were elucidated by 1D and 2D NMR spectroscopic data. Of these compounds, 6 exhibited the strongest cytotoxicity against the four tested human cancer cell lines (IC50 of about 10 μM against Hep-2 larynx cancer cells).

AB - An indole alkaloid, 2-(5-hydroxy-1H-indol-3-yl)-2-oxo-acetic acid (1) isolated for the first time from nature, in addition to the nine known compounds 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (2), alocasin B (3), hyrtiosin B (4), α-monopalmitin (5), 1-O-β-D-glucopyranosyl-(2S, 3R, 4E, 8Z)-2-[(2(R)-hydroctadecanoyl) amido]-4,8-octadecadiene-1,3-diol (6), 3-epi-betulinic acid (7), 3-epi-ursolic acid (8), β-sitosterol (9) and β-sitosterol 3-O-β-D-glucoside (10) were isolated from the rhizomes of Alocasia macrorrhiza (Araceae). Their structures were elucidated by 1D and 2D NMR spectroscopic data. Of these compounds, 6 exhibited the strongest cytotoxicity against the four tested human cancer cell lines (IC50 of about 10 μM against Hep-2 larynx cancer cells).

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KW - epi-triterpene

KW - indole alkaloids

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ER -

Cytotoxic constituents of Alocasia macrorrhiza

Abstract

Keywords

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