Correlation between lncRNAs with human molecular chaperons in cancer immunopathogenesis and drug resistance

  • Chou Yi Hsu
  • , Nabaa Hisham Ateya
  • , Enwa Felix Oghenemaro
  • , Deepak Nathiya
  • , Parjinder Kaur
  • , Ahmed Hjazi
  • , Mamdouh Eldesoqui
  • , Alexey Yumashev
  • , Munther Kadhim Abosaoda
  • , Mustafa Adnan Abdulrahman

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The development of cancer immunology heavily relies on the interaction between long non-coding RNAs (lncRNAs) and molecular chaperones. By participating in gene regulation, lncRNAs interact with molecular chaperones, which play a critical role in protein folding and stress responses, to influence oncogenic pathways. This interaction has an impact on both the immune cells within the tumor microenvironment and the tumor cells themselves. Understanding these mechanisms provides valuable insights into innovative approaches for diagnosis and treatment. Targeting the lncRNA-chaperone axis has the potential to strengthen anti-tumor immunity and enhance cancer treatment outcomes. Further research is necessary to uncover specific associations, identify biomarkers, and develop personalized therapies aimed at disrupting this axis, which could potentially revolutionize cancer diagnosis and treatment.

Original languageEnglish
Article number113309
JournalInternational Immunopharmacology
Volume143
DOIs
StatePublished - 25 Dec 2024

Keywords

  • Cancer
  • Chaperons
  • Drug resistance
  • Immunopathogenesis
  • lncRNA

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