Chalcone-based imidazo[2,1-b]thiazole derivatives: synthesis, crystal structure, potent anticancer activity, and computational studies

Biochemistry, Genetics and Molecular Biology

• Anticancer 100%
• Crystal Structure 100%
• Docking (Molecular) 100%
• IC50 100%
• Flow Cytometry 100%
• Antineoplastic Activity 100%
• Cancer Cell 100%
• Caspase 100%
• Thiazole 100%
• Antiproliferative Activity 100%
• Enzyme 50%
• Programmed Cell Death 50%
• Binding Energy 50%
• Pharmacokinetic Properties 50%
• Binding Site 50%
• Caspase 3 50%
• X Ray Diffraction 50%
• Fibroblast 50%
• Resolution (Mass Spectrometry) 50%
• Chemical Structure 50%
• Membrane Damage 50%
• Mitochondrial Membrane 50%
• Outer Mitochondrial Membrane 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Malignant Neoplasm 100%
• Chalcone 100%
• IC50 100%
• Flow Cytometry 100%
• Caspase 100%
• Membrane Damage 100%
• Antiinfective Agent 50%
• Carbon 13 50%
• Antiproliferative Activity 50%
• Pharmacokinetic 50%
• Electrospray Ionization 50%
• Anticarcinogen 50%
• Binding Site 50%
• Caspase 3 50%
• Colorectal Carcinoma 50%
• Lung Carcinoma 50%
• Breast Adenocarcinoma 50%
• Carboplatin 50%

Chemistry

• Crystal Structure 100%
• Thiazole 100%
• Isothermal Titration Calorimetry 100%
• IC50 20%
• Cytometry 20%
• Antiproliferative 20%
• 1H NMR Spectroscopy 10%
• 13C NMR Spectroscopy 10%
• High Resolution Mass Spectrometry (HRMS) 10%
• Pharmacokinetics 10%
• Electrospray Ionization 10%
• Binding Energy 10%
• Binding Site 10%
• Single-Crystal X-Ray Crystallography 10%
• Apoptotic 10%
• DNA 10%
• Antineoplastic Agent 10%