TY - JOUR
T1 - Carotenoids
T2 - Role in Neurodegenerative Diseases Remediation
AU - Gandla, Kumaraswamy
AU - Babu, Ancha Kishore
AU - Unnisa, Aziz
AU - Sharma, Indu
AU - Singh, Laliteshwar Pratap
AU - Haque, Mahammad Akiful
AU - Dashputre, Neelam Laxman
AU - Baig, Shahajan
AU - Siddiqui, Falak A.
AU - Khandaker, Mayeen Uddin
AU - Almujally, Abdullah
AU - Tamam, Nissren
AU - Sulieman, Abdelmoneim
AU - Khan, Sharuk L.
AU - Emran, Talha Bin
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/3
Y1 - 2023/3
N2 - Numerous factors can contribute to the development of neurodegenerative disorders (NDs), such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis. Oxidative stress (OS), a fairly common ND symptom, can be caused by more reactive oxygen species being made. In addition, the pathological state of NDs, which includes a high number of protein aggregates, could make chronic inflammation worse by activating microglia. Carotenoids, often known as “CTs”, are pigments that exist naturally and play a vital role in the prevention of several brain illnesses. CTs are organic pigments with major significance in ND prevention. More than 600 CTs have been discovered in nature, and they may be found in a wide variety of creatures. Different forms of CTs are responsible for the red, yellow, and orange pigments seen in many animals and plants. Because of their unique structure, CTs exhibit a wide range of bioactive effects, such as anti-inflammatory and antioxidant effects. The preventive effects of CTs have led researchers to find a strong correlation between CT levels in the body and the avoidance and treatment of several ailments, including NDs. To further understand the connection between OS, neuroinflammation, and NDs, a literature review has been compiled. In addition, we have focused on the anti-inflammatory and antioxidant properties of CTs for the treatment and management of NDs.
AB - Numerous factors can contribute to the development of neurodegenerative disorders (NDs), such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, Huntington’s disease, and multiple sclerosis. Oxidative stress (OS), a fairly common ND symptom, can be caused by more reactive oxygen species being made. In addition, the pathological state of NDs, which includes a high number of protein aggregates, could make chronic inflammation worse by activating microglia. Carotenoids, often known as “CTs”, are pigments that exist naturally and play a vital role in the prevention of several brain illnesses. CTs are organic pigments with major significance in ND prevention. More than 600 CTs have been discovered in nature, and they may be found in a wide variety of creatures. Different forms of CTs are responsible for the red, yellow, and orange pigments seen in many animals and plants. Because of their unique structure, CTs exhibit a wide range of bioactive effects, such as anti-inflammatory and antioxidant effects. The preventive effects of CTs have led researchers to find a strong correlation between CT levels in the body and the avoidance and treatment of several ailments, including NDs. To further understand the connection between OS, neuroinflammation, and NDs, a literature review has been compiled. In addition, we have focused on the anti-inflammatory and antioxidant properties of CTs for the treatment and management of NDs.
KW - carotenoids
KW - neurodegeneration
KW - neuroinflammation
KW - oxidative stress
KW - oxidative stress
KW - reactive oxygen species
UR - https://www.scopus.com/pages/publications/85151425824
U2 - 10.3390/brainsci13030457
DO - 10.3390/brainsci13030457
M3 - Review article
AN - SCOPUS:85151425824
SN - 2076-3425
VL - 13
JO - Brain Sciences
JF - Brain Sciences
IS - 3
M1 - 457
ER -