TY - JOUR
T1 - Cardioprotective potential of Lavandula stoechas against isoprenaline-induced myocardial necrosis in rats
AU - Siddiqui, Mohd Aftab
AU - Siddiqui, Hefazat Hussain
AU - Badruddeen,
AU - Khalid, Mohammad
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/12
Y1 - 2023/12
N2 - This study assessed Lavandula stoechas flower extract's impact on Isoprenaline-induced myocardial necrosis in rats. Five groups of five rats each were used. Group I received 1 ml/kg normal saline orally for 13 days, Group II received 10 ml/kg normal saline orally, Group III received 200 mg/kg Lavandula stoechas extract orally, Group IV received 400 mg/kg Lavandula stoechas extract orally, and Group V received 10 mg/kg Metoprolol orally. On days 14 and 15, Group I received 0.5 ml/kg subcutaneous normal saline, and Groups II to V received 85 mg/kg Isoprenaline subcutaneously. On day 16, rats were weighed, and cardiac blood samples were collected. Serum was analyzed for total protein, triglycerides, and cardiac enzymes (cardiac injury markers). Rats were sacrificed, and heart tissues were histologically examined. Results showed significant serum marker enzyme reductions (p < 0.01) in Lavandula stoechas-treated rats. Total protein and triglyceride levels (p < 0.01) decreased, and heart weight-to-body weight ratio (p < 0.05) decreased in Lavandula stoechas-treated rats. Histopathology confirmed the extract's protective effect. In conclusion, Lavandula stoechas flower extract offers protection against Isoprenaline-induced myocardial infarction in rats.
AB - This study assessed Lavandula stoechas flower extract's impact on Isoprenaline-induced myocardial necrosis in rats. Five groups of five rats each were used. Group I received 1 ml/kg normal saline orally for 13 days, Group II received 10 ml/kg normal saline orally, Group III received 200 mg/kg Lavandula stoechas extract orally, Group IV received 400 mg/kg Lavandula stoechas extract orally, and Group V received 10 mg/kg Metoprolol orally. On days 14 and 15, Group I received 0.5 ml/kg subcutaneous normal saline, and Groups II to V received 85 mg/kg Isoprenaline subcutaneously. On day 16, rats were weighed, and cardiac blood samples were collected. Serum was analyzed for total protein, triglycerides, and cardiac enzymes (cardiac injury markers). Rats were sacrificed, and heart tissues were histologically examined. Results showed significant serum marker enzyme reductions (p < 0.01) in Lavandula stoechas-treated rats. Total protein and triglyceride levels (p < 0.01) decreased, and heart weight-to-body weight ratio (p < 0.05) decreased in Lavandula stoechas-treated rats. Histopathology confirmed the extract's protective effect. In conclusion, Lavandula stoechas flower extract offers protection against Isoprenaline-induced myocardial infarction in rats.
KW - Ethanol extract
KW - Isoprenaline
KW - Lavandula stoechas
KW - Myocardial infarction
UR - https://www.scopus.com/pages/publications/85201571673
U2 - 10.1016/j.ipha.2023.08.007
DO - 10.1016/j.ipha.2023.08.007
M3 - Article
AN - SCOPUS:85201571673
SN - 2949-866X
VL - 1
SP - 260
EP - 267
JO - Intelligent Pharmacy
JF - Intelligent Pharmacy
IS - 4
ER -