Biotransformation of Khellin to Khellol by Aspergillus niger and the evaluation of their biological activities

Ahmed Ashour; Saleh El-Sharkawy; Mohamed Amer; Fatma Abdel Bar; Amira Mera; Toshiro Nagata; Ryuichiro Kondo; Kuniyoshi Shimizu

doi:10.2174/1874847320130628001

Biotransformation of Khellin to Khellol by Aspergillus niger and the evaluation of their biological activities

Ahmed Ashour
, Saleh El-Sharkawy
, Mohamed Amer
, Fatma Abdel Bar
, Amira Mera
, Toshiro Nagata
, Ryuichiro Kondo
, Kuniyoshi Shimizu

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Biotransformation of khellin using Aspergillus niger ATCC 10549 resulted in the production of khellol. The biological activities of the transformed product and khellin were established by antioxidant and acetylcholine esterase inhibitory assays. Khellol exhibited a higher degree of antioxidant and acetylcholine esterase inhibitory activities compared to khellin. This is the first report on the biotransformation of khellin by microorganisms and the first evaluation of the neuroprotective activity of either khellin or khellol.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Open Bioactive Compounds Journal
Volume	4
DOIs	https://doi.org/10.2174/1874847320130628001
State	Published - 2013
Externally published	Yes

Keywords

Biotransformation
Khellin
Khellol
Neuroprotective

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10.2174/1874847320130628001

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title = "Biotransformation of Khellin to Khellol by Aspergillus niger and the evaluation of their biological activities",

abstract = "Biotransformation of khellin using Aspergillus niger ATCC 10549 resulted in the production of khellol. The biological activities of the transformed product and khellin were established by antioxidant and acetylcholine esterase inhibitory assays. Khellol exhibited a higher degree of antioxidant and acetylcholine esterase inhibitory activities compared to khellin. This is the first report on the biotransformation of khellin by microorganisms and the first evaluation of the neuroprotective activity of either khellin or khellol.",

keywords = "Biotransformation, Khellin, Khellol, Neuroprotective",

author = "Ahmed Ashour and Saleh El-Sharkawy and Mohamed Amer and Bar, \{Fatma Abdel\} and Amira Mera and Toshiro Nagata and Ryuichiro Kondo and Kuniyoshi Shimizu",

year = "2013",

doi = "10.2174/1874847320130628001",

language = "English",

volume = "4",

pages = "1--3",

journal = "Open Bioactive Compounds Journal",

issn = "1874-8473",

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T1 - Biotransformation of Khellin to Khellol by Aspergillus niger and the evaluation of their biological activities

AU - Ashour, Ahmed

AU - El-Sharkawy, Saleh

AU - Amer, Mohamed

AU - Bar, Fatma Abdel

AU - Mera, Amira

AU - Nagata, Toshiro

AU - Kondo, Ryuichiro

AU - Shimizu, Kuniyoshi

PY - 2013

Y1 - 2013

N2 - Biotransformation of khellin using Aspergillus niger ATCC 10549 resulted in the production of khellol. The biological activities of the transformed product and khellin were established by antioxidant and acetylcholine esterase inhibitory assays. Khellol exhibited a higher degree of antioxidant and acetylcholine esterase inhibitory activities compared to khellin. This is the first report on the biotransformation of khellin by microorganisms and the first evaluation of the neuroprotective activity of either khellin or khellol.

AB - Biotransformation of khellin using Aspergillus niger ATCC 10549 resulted in the production of khellol. The biological activities of the transformed product and khellin were established by antioxidant and acetylcholine esterase inhibitory assays. Khellol exhibited a higher degree of antioxidant and acetylcholine esterase inhibitory activities compared to khellin. This is the first report on the biotransformation of khellin by microorganisms and the first evaluation of the neuroprotective activity of either khellin or khellol.

KW - Biotransformation

KW - Khellin

KW - Khellol

KW - Neuroprotective

UR - https://www.scopus.com/pages/publications/84888041830

U2 - 10.2174/1874847320130628001

DO - 10.2174/1874847320130628001

M3 - Article

AN - SCOPUS:84888041830

SN - 1874-8473

VL - 4

SP - 1

EP - 3

JO - Open Bioactive Compounds Journal

JF - Open Bioactive Compounds Journal

ER -

Biotransformation of Khellin to Khellol by Aspergillus niger and the evaluation of their biological activities

Abstract

Keywords

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