Biotransformation, multifunctional recycling mechanism of nanostructures, and evaluation of the safety of nanoscale materials

Debjyoti Talukdar, Parveen Kumar, Benu Chaudhary, Deepak Sharma, Nishant Yadav, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Waleed Hassan Almalki, Sami I. Alzarea, Imran Kazmi, Ashutosh Pareek, Gaurav Gupta, Madan Mohan Gupta

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Current evidence of concept analyses recommending nanotechnology for biomedical uses abounds in recent research. The area of biotechnology interfaces with nanostructures, reconfigures their composition, and alters their characteristics; which influences the dispersion of the particles, the biotransformation they cause, and their potential toxic effect. It is vital to link the idea of the lifecycle of nanostructures to the biological impacts and use methodologies to identify, estimate, and track the gradual bioprocessing of nanostructures in vivo, from a body-wide level to a nanoscopic size. This is necessary because understanding how nanostructures processing, degradation, persistence, and recycling predict potential exposure risks. The safe implementation of nanotechnology-based products in biomedical applications necessitates an extensive understanding of the recycling and transformations of nanomaterials in a living organism. Long-term fate in the body is crucial, as it governs potential environmental risks to human health. Strategies may be used to manage the long-term outcome of nanostructures in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. The lifespan of nanoparticles, a flexible and biocompatible category of nanostructures that have made it into clinical trials, is the subject of this article. Strategies may be used to manage the long-term outcome of nanoparticles in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. This review explained the safety of nanoscale materials, biotransformation, and the multifunctional recycling mechanism of nanostructures.

Original languageEnglish
Pages (from-to)76-86
Number of pages11
JournalParticuology
Volume82
DOIs
StatePublished - Nov 2023

Keywords

  • Biotransformation
  • Environmental risk
  • Nanoparticle
  • Nanostructure
  • Toxic effect

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