Bioactive acetophenones from Plectranthus venteri

Johanna E. Maree; Proma Khondkar; Awo A. Kwapong; Blessing M. Oyedemi; Tariq M. Aljarba; Paul Stapleton; Alvaro M. Viljoen; Simon Gibbons

doi:10.1016/j.phytol.2014.10.021

Bioactive acetophenones from Plectranthus venteri

Johanna E. Maree
, Proma Khondkar
, Awo A. Kwapong
, Blessing M. Oyedemi
, Tariq M. Aljarba
, Paul Stapleton
, Alvaro M. Viljoen
, Simon Gibbons

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

In a project to investigate the chemistry of South African Plectranthus species, from the dichloromethane extract of the aerial parts of Plectranthus venteri, we isolated two known natural product acetophenones, namely 2-hydroxy-3,4,5,6-tetramethoxy-acetophenone (1) and 2-hydroxy-4,5,6-trimethoxy-acetophenone (2). Structures were assigned using NMR spectroscopy and HRTOFESIMS. Compound 1 was previously synthesised as a precursor to the polymethoxylated flavone nobiletin. The acetophenones exhibited remarkable inhibitory activities against the transfer of the IncW plasmid R7K in a bacterial plasmid transfer inhibition assay.

Original language	English
Pages (from-to)	cxli-cxliv
Journal	Phytochemistry Letters
Volume	10
DOIs	https://doi.org/10.1016/j.phytol.2014.10.021
State	Published - Dec 2014
Externally published	Yes

Keywords

Acetophenones
Bacterial plasmid transfer inhibition
Lamiaceae
Plectranthus venteri

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10.1016/j.phytol.2014.10.021

Cite this

@article{8a068993255a47e2b6bdfeefcf6e7f89,

title = "Bioactive acetophenones from Plectranthus venteri",

abstract = "In a project to investigate the chemistry of South African Plectranthus species, from the dichloromethane extract of the aerial parts of Plectranthus venteri, we isolated two known natural product acetophenones, namely 2-hydroxy-3,4,5,6-tetramethoxy-acetophenone (1) and 2-hydroxy-4,5,6-trimethoxy-acetophenone (2). Structures were assigned using NMR spectroscopy and HRTOFESIMS. Compound 1 was previously synthesised as a precursor to the polymethoxylated flavone nobiletin. The acetophenones exhibited remarkable inhibitory activities against the transfer of the IncW plasmid R7K in a bacterial plasmid transfer inhibition assay.",

keywords = "Acetophenones, Bacterial plasmid transfer inhibition, Lamiaceae, Plectranthus venteri",

author = "Maree, \{Johanna E.\} and Proma Khondkar and Kwapong, \{Awo A.\} and Oyedemi, \{Blessing M.\} and Aljarba, \{Tariq M.\} and Paul Stapleton and Viljoen, \{Alvaro M.\} and Simon Gibbons",

year = "2014",

month = dec,

doi = "10.1016/j.phytol.2014.10.021",

language = "English",

volume = "10",

pages = "cxli--cxliv",

journal = "Phytochemistry Letters",

issn = "1874-3900",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Bioactive acetophenones from Plectranthus venteri

AU - Maree, Johanna E.

AU - Khondkar, Proma

AU - Kwapong, Awo A.

AU - Oyedemi, Blessing M.

AU - Aljarba, Tariq M.

AU - Stapleton, Paul

AU - Viljoen, Alvaro M.

AU - Gibbons, Simon

PY - 2014/12

Y1 - 2014/12

N2 - In a project to investigate the chemistry of South African Plectranthus species, from the dichloromethane extract of the aerial parts of Plectranthus venteri, we isolated two known natural product acetophenones, namely 2-hydroxy-3,4,5,6-tetramethoxy-acetophenone (1) and 2-hydroxy-4,5,6-trimethoxy-acetophenone (2). Structures were assigned using NMR spectroscopy and HRTOFESIMS. Compound 1 was previously synthesised as a precursor to the polymethoxylated flavone nobiletin. The acetophenones exhibited remarkable inhibitory activities against the transfer of the IncW plasmid R7K in a bacterial plasmid transfer inhibition assay.

AB - In a project to investigate the chemistry of South African Plectranthus species, from the dichloromethane extract of the aerial parts of Plectranthus venteri, we isolated two known natural product acetophenones, namely 2-hydroxy-3,4,5,6-tetramethoxy-acetophenone (1) and 2-hydroxy-4,5,6-trimethoxy-acetophenone (2). Structures were assigned using NMR spectroscopy and HRTOFESIMS. Compound 1 was previously synthesised as a precursor to the polymethoxylated flavone nobiletin. The acetophenones exhibited remarkable inhibitory activities against the transfer of the IncW plasmid R7K in a bacterial plasmid transfer inhibition assay.

KW - Acetophenones

KW - Bacterial plasmid transfer inhibition

KW - Lamiaceae

KW - Plectranthus venteri

UR - https://www.scopus.com/pages/publications/84914703007

U2 - 10.1016/j.phytol.2014.10.021

DO - 10.1016/j.phytol.2014.10.021

M3 - Article

AN - SCOPUS:84914703007

SN - 1874-3900

VL - 10

SP - cxli-cxliv

JO - Phytochemistry Letters

JF - Phytochemistry Letters

ER -

Bioactive acetophenones from Plectranthus venteri

Abstract

Keywords

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