Applications of Electrochemical and Optical Biosensing Techniques Based on Nanomaterials for Detection of SARS-COV-2 Specific Antibodies: An Update Review

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS CoV-2) caused the burden of coronavirus infectious disease 2019 (COVID-19) and spread all of the world. Evaluation of antibodies is the most typical diagnostic method is utilized to detect SARS-COV-2. Quick and high-specific diagnosis of specific antibodies can be the best way to evaluate the vaccine efficiency and decrease the number of the disease. In this study, before discussing the types of biosensors designed for the specific detection of SARS CoV-2 virus in these few years, we have summarized the serological methods in antibody detection and pointed out some of its advantages and disadvantages. In recent decade, biosensors have appeared to complement ELISA and PCR for pathogen detection. In two years ago, Electrochemical, colorimetric and fluorescence biosensors based on various nanomaterials are developed for SARS-COV-2 specific Abs detection with high specificity and sensitivity. This article specifically deals with the detection of specific antibodies of Covid-19 by biosensor methods and it is an update of similar articles. Considering that one of our goals was to investigate new biosensor methods for diagnosis, we tried to select studies related to Covid-19 specific Abs mostly between 2019 and 2021.