Antiulcer Activity of Different Extracts of Anvillea garcinii and Isolation of Two New Secondary Metabolites

Shagufta Perveen; Ghada Ahmed Fawzy; Areej Mohammad Al-Taweel; Raha Saud Orfali; Hasan Soliman Yusufoglu; Maged Saad Abdel-Kader; Ruba Mahmoud Al-Sabbagh

doi:10.1515/chem-2018-0037

Antiulcer Activity of Different Extracts of Anvillea garcinii and Isolation of Two New Secondary Metabolites

Shagufta Perveen
, Ghada Ahmed Fawzy
, Areej Mohammad Al-Taweel
, Raha Saud Orfali
, Hasan Soliman Yusufoglu
, Maged Saad Abdel-Kader
, Ruba Mahmoud Al-Sabbagh

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Anvillea garcinii (AG, Asteraceae) commonly called "nougd" in Arabic is traditionally used for the treatment of different gastrointestinal disorders. This study evaluates the effects of ethanol, chloroform and n-butanol extracts of AG on ulcerative colitis induced by various ulcerogens in rats and the isolation of new secondary metabolites. Ethanol extracts of the leaf of the AG demonstrated a powerful anti-ulcer activity which could be attributed to the synergistic effect of its constituents. Therefore, our results would be the first proof of traditional use of AG as an antiulcer ailment.

Original language	English
Pages (from-to)	437-445
Number of pages	9
Journal	Open Chemistry
Volume	16
Issue number	1
DOIs	https://doi.org/10.1515/chem-2018-0037
State	Published - 2018

Keywords

anti-ulcer
Anvillea garcinii
Flavonoid glycoside
Sesquiterpene glucoside

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@article{1b3313478c7e47c3b9461d5fba39f248,

title = "Antiulcer Activity of Different Extracts of Anvillea garcinii and Isolation of Two New Secondary Metabolites",

abstract = "Anvillea garcinii (AG, Asteraceae) commonly called {"}nougd{"} in Arabic is traditionally used for the treatment of different gastrointestinal disorders. This study evaluates the effects of ethanol, chloroform and n-butanol extracts of AG on ulcerative colitis induced by various ulcerogens in rats and the isolation of new secondary metabolites. Ethanol extracts of the leaf of the AG demonstrated a powerful anti-ulcer activity which could be attributed to the synergistic effect of its constituents. Therefore, our results would be the first proof of traditional use of AG as an antiulcer ailment.",

keywords = "anti-ulcer, Anvillea garcinii, Flavonoid glycoside, Sesquiterpene glucoside",

author = "Shagufta Perveen and Fawzy, \{Ghada Ahmed\} and Al-Taweel, \{Areej Mohammad\} and Orfali, \{Raha Saud\} and \{Soliman Yusufoglu\}, Hasan and Abdel-Kader, \{Maged Saad\} and Al-Sabbagh, \{Ruba Mahmoud\}",

note = "Publisher Copyright: {\textcopyright} 2018 Shagufta Perveen et al.",

year = "2018",

doi = "10.1515/chem-2018-0037",

language = "English",

volume = "16",

pages = "437--445",

journal = "Open Chemistry",

issn = "2391-5420",

publisher = "Walter de Gruyter GmbH",

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}

TY - JOUR

T1 - Antiulcer Activity of Different Extracts of Anvillea garcinii and Isolation of Two New Secondary Metabolites

AU - Perveen, Shagufta

AU - Fawzy, Ghada Ahmed

AU - Al-Taweel, Areej Mohammad

AU - Orfali, Raha Saud

AU - Soliman Yusufoglu, Hasan

AU - Abdel-Kader, Maged Saad

AU - Al-Sabbagh, Ruba Mahmoud

PY - 2018

Y1 - 2018

N2 - Anvillea garcinii (AG, Asteraceae) commonly called "nougd" in Arabic is traditionally used for the treatment of different gastrointestinal disorders. This study evaluates the effects of ethanol, chloroform and n-butanol extracts of AG on ulcerative colitis induced by various ulcerogens in rats and the isolation of new secondary metabolites. Ethanol extracts of the leaf of the AG demonstrated a powerful anti-ulcer activity which could be attributed to the synergistic effect of its constituents. Therefore, our results would be the first proof of traditional use of AG as an antiulcer ailment.

AB - Anvillea garcinii (AG, Asteraceae) commonly called "nougd" in Arabic is traditionally used for the treatment of different gastrointestinal disorders. This study evaluates the effects of ethanol, chloroform and n-butanol extracts of AG on ulcerative colitis induced by various ulcerogens in rats and the isolation of new secondary metabolites. Ethanol extracts of the leaf of the AG demonstrated a powerful anti-ulcer activity which could be attributed to the synergistic effect of its constituents. Therefore, our results would be the first proof of traditional use of AG as an antiulcer ailment.

KW - anti-ulcer

KW - Anvillea garcinii

KW - Flavonoid glycoside

KW - Sesquiterpene glucoside

UR - https://www.scopus.com/pages/publications/85047828391

U2 - 10.1515/chem-2018-0037

DO - 10.1515/chem-2018-0037

M3 - Article

AN - SCOPUS:85047828391

SN - 2391-5420

VL - 16

SP - 437

EP - 445

JO - Open Chemistry

JF - Open Chemistry

IS - 1

ER -

Antiulcer Activity of Different Extracts of Anvillea garcinii and Isolation of Two New Secondary Metabolites

Abstract

Keywords

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