Antioxidant activity of covolvulus hystrix Vahl and its chemical constituents

Abd El Raheim Mohammed Donia; Saleh Ibrahim Alqasoumi; Amani Shafeek Awaad; Lyle Cracker

Antioxidant activity of covolvulus hystrix Vahl and its chemical constituents

Abd El Raheim Mohammed Donia
, Saleh Ibrahim Alqasoumi
, Amani Shafeek Awaad
, Lyle Cracker

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Total alcohol and successive extracts (diethyl ether, chloroform, ethyl acetate and n-butanol) of Covolvulus hystrix Vahl were screened for their antioxidant activity using free radical 2-2- diphenyl-1-picrylhydrazyl (DPPH) and Trolox as reference substance. The tested extracts showed variable antioxidant activities. The highest antioxidant activity was achieved in total alcohol (48.32%) followed by ethyl acetate (37. 8 %) and nbutanol (32.96 %) extracts. From the ethyl acetate extract four compounds were isolated and identified as quercetin, quercetin 3-0-rutinoside and quercetin-7-O-rhamnoside in addition to ferulic acid using different spectroscopic analysis such as, ¹HNMR, ¹³CNMR, COSY, HMBC and HMQC.

Original language	English
Pages (from-to)	143-147
Number of pages	5
Journal	Pakistan Journal of Pharmaceutical Sciences
Volume	24
Issue number	2
State	Published - Apr 2011
Externally published	Yes

Keywords

Antioxidant activity
Convolvulus hystrix
Ferulic acid
Flavonoids
Total phenolics

Cite this

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title = "Antioxidant activity of covolvulus hystrix Vahl and its chemical constituents",

abstract = "Total alcohol and successive extracts (diethyl ether, chloroform, ethyl acetate and n-butanol) of Covolvulus hystrix Vahl were screened for their antioxidant activity using free radical 2-2- diphenyl-1-picrylhydrazyl (DPPH) and Trolox as reference substance. The tested extracts showed variable antioxidant activities. The highest antioxidant activity was achieved in total alcohol (48.32\%) followed by ethyl acetate (37. 8 \%) and nbutanol (32.96 \%) extracts. From the ethyl acetate extract four compounds were isolated and identified as quercetin, quercetin 3-0-rutinoside and quercetin-7-O-rhamnoside in addition to ferulic acid using different spectroscopic analysis such as, 1HNMR, 13CNMR, COSY, HMBC and HMQC.",

keywords = "Antioxidant activity, Convolvulus hystrix, Ferulic acid, Flavonoids, Total phenolics",

author = "Donia, \{Abd El Raheim Mohammed\} and Alqasoumi, \{Saleh Ibrahim\} and Awaad, \{Amani Shafeek\} and Lyle Cracker",

year = "2011",

month = apr,

language = "English",

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pages = "143--147",

journal = "Pakistan Journal of Pharmaceutical Sciences",

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publisher = "Pakistan Journal of Pharmaceutical Sciences",

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TY - JOUR

T1 - Antioxidant activity of covolvulus hystrix Vahl and its chemical constituents

AU - Donia, Abd El Raheim Mohammed

AU - Alqasoumi, Saleh Ibrahim

AU - Awaad, Amani Shafeek

AU - Cracker, Lyle

PY - 2011/4

Y1 - 2011/4

N2 - Total alcohol and successive extracts (diethyl ether, chloroform, ethyl acetate and n-butanol) of Covolvulus hystrix Vahl were screened for their antioxidant activity using free radical 2-2- diphenyl-1-picrylhydrazyl (DPPH) and Trolox as reference substance. The tested extracts showed variable antioxidant activities. The highest antioxidant activity was achieved in total alcohol (48.32%) followed by ethyl acetate (37. 8 %) and nbutanol (32.96 %) extracts. From the ethyl acetate extract four compounds were isolated and identified as quercetin, quercetin 3-0-rutinoside and quercetin-7-O-rhamnoside in addition to ferulic acid using different spectroscopic analysis such as, 1HNMR, 13CNMR, COSY, HMBC and HMQC.

AB - Total alcohol and successive extracts (diethyl ether, chloroform, ethyl acetate and n-butanol) of Covolvulus hystrix Vahl were screened for their antioxidant activity using free radical 2-2- diphenyl-1-picrylhydrazyl (DPPH) and Trolox as reference substance. The tested extracts showed variable antioxidant activities. The highest antioxidant activity was achieved in total alcohol (48.32%) followed by ethyl acetate (37. 8 %) and nbutanol (32.96 %) extracts. From the ethyl acetate extract four compounds were isolated and identified as quercetin, quercetin 3-0-rutinoside and quercetin-7-O-rhamnoside in addition to ferulic acid using different spectroscopic analysis such as, 1HNMR, 13CNMR, COSY, HMBC and HMQC.

KW - Antioxidant activity

KW - Convolvulus hystrix

KW - Ferulic acid

KW - Flavonoids

KW - Total phenolics

UR - https://www.scopus.com/pages/publications/79953840356

M3 - Article

C2 - 21454162

AN - SCOPUS:79953840356

SN - 1011-601X

VL - 24

SP - 143

EP - 147

JO - Pakistan Journal of Pharmaceutical Sciences

JF - Pakistan Journal of Pharmaceutical Sciences

IS - 2

ER -

Antioxidant activity of covolvulus hystrix Vahl and its chemical constituents

Abstract

Keywords

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