TY - JOUR
T1 - Antimony (III) oxide and calcium phosphate doped with carbon nanotubes in PVA/HA matrix for wound dressing applications
AU - Elabbasy, Mohamed Tharwat
AU - Almarshadi, Fahad Awwadh
AU - Alshammari, Muteb H.
AU - Othman, Mohamed S.
AU - Ghoniem, Mohamed E.
AU - Samak, Mai A.
AU - Domyati, Doaa
AU - El-Morsy, M. A.
AU - Farea, M. O.
N1 - Publisher Copyright:
© 2025 Elsevier B.V.
PY - 2025/9/1
Y1 - 2025/9/1
N2 - This study investigates the development of nanocomposite wound dressing films composed of a poly(vinyl alcohol)/hyaluronic acid (PVA/HA) matrix incorporating antimony(III) oxide (Sb2O3), calcium phosphate (Ca3(PO4)2), and carbon nanotubes (CNTs). The physicochemical and biological properties of these cast films were systematically evaluated. Contact angle measurements revealed enhanced hydrophilicity upon nanoparticle incorporation, with the Ca3(PO4)2/Sb2O3@PVA/HA film demonstrating the highest wettability, exhibiting a contact angle of 32.3 ± 2.46°. The refractive index varied from 1.69 for PVA/HA to 1.71 for Sb2O3@PVA/HA. In vitro cytotoxicity assays confirmed biocompatibility, showing a cell viability ratio of approximately 123 % for human normal cells after three days of culture. Surface morphology analysis indicated significant alterations with the addition of nanoparticles. Notably, the Ca3(PO4)2/Sb2O3/CNT@PVA/HA film exhibited a substantial inhibition zone of 25.9 ± 1.1 mm against Escherichia coli. This film exhibited a porosity of 48.1 ± 6.1 %, with pore sizes ranging from 120 to 350 nm, indicating a potential for enhanced cellular infiltration and proliferation. The release of calcium (Ca2+) and antimony (Sb3+) ions reached 37 ± 2.7 ppm and 11 ± 1.2 ppm, respectively, after 16 h. The films exhibited significant swelling behavior, reaching 450.6 ± 15.9 % after 12 h, accompanied by an elongation at break of 168.13 ± 11.29 % and a tensile strength of 35.94 ± 0.64 MPa. These results collectively demonstrate the potential of these nanocomposite films for diverse biomedical applications, particularly in wound healing.
AB - This study investigates the development of nanocomposite wound dressing films composed of a poly(vinyl alcohol)/hyaluronic acid (PVA/HA) matrix incorporating antimony(III) oxide (Sb2O3), calcium phosphate (Ca3(PO4)2), and carbon nanotubes (CNTs). The physicochemical and biological properties of these cast films were systematically evaluated. Contact angle measurements revealed enhanced hydrophilicity upon nanoparticle incorporation, with the Ca3(PO4)2/Sb2O3@PVA/HA film demonstrating the highest wettability, exhibiting a contact angle of 32.3 ± 2.46°. The refractive index varied from 1.69 for PVA/HA to 1.71 for Sb2O3@PVA/HA. In vitro cytotoxicity assays confirmed biocompatibility, showing a cell viability ratio of approximately 123 % for human normal cells after three days of culture. Surface morphology analysis indicated significant alterations with the addition of nanoparticles. Notably, the Ca3(PO4)2/Sb2O3/CNT@PVA/HA film exhibited a substantial inhibition zone of 25.9 ± 1.1 mm against Escherichia coli. This film exhibited a porosity of 48.1 ± 6.1 %, with pore sizes ranging from 120 to 350 nm, indicating a potential for enhanced cellular infiltration and proliferation. The release of calcium (Ca2+) and antimony (Sb3+) ions reached 37 ± 2.7 ppm and 11 ± 1.2 ppm, respectively, after 16 h. The films exhibited significant swelling behavior, reaching 450.6 ± 15.9 % after 12 h, accompanied by an elongation at break of 168.13 ± 11.29 % and a tensile strength of 35.94 ± 0.64 MPa. These results collectively demonstrate the potential of these nanocomposite films for diverse biomedical applications, particularly in wound healing.
KW - Antimony oxide
KW - Calcium phosphate
KW - Carbon nanotubes
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=105003972394&partnerID=8YFLogxK
U2 - 10.1016/j.matchemphys.2025.130933
DO - 10.1016/j.matchemphys.2025.130933
M3 - Article
AN - SCOPUS:105003972394
SN - 0254-0584
VL - 341
JO - Materials Chemistry and Physics
JF - Materials Chemistry and Physics
M1 - 130933
ER -