Antibacterial and antifungal sesquiterpenoids from aerial parts of anvillea garcinii

Shagufta Perveen; Jawaher Alqahtani; Raha Orfali; Hanan Y. Aati; Areej M. Al-Taweel; Taghreed A. Ibrahim; Afsar Khan; Hasan Soliman Yusufoglu; Maged S. Abdel-Kader; Orazio Taglialatela-Scafati

doi:10.3390/molecules25071730

Antibacterial and antifungal sesquiterpenoids from aerial parts of anvillea garcinii

Shagufta Perveen
, Jawaher Alqahtani
, Raha Orfali
, Hanan Y. Aati
, Areej M. Al-Taweel
, Taghreed A. Ibrahim
, Afsar Khan
, Hasan Soliman Yusufoglu
, Maged S. Abdel-Kader
, Orazio Taglialatela-Scafati

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia- 11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated fromthe leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3-9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1-9 were screened against seven different pathogenic microbes, and compounds 1-3 showed a potent antifungal activity.

Original language	English
Article number	molecules25071730
Journal	Molecules
Volume	25
Issue number	7
DOIs	https://doi.org/10.3390/molecules25071730
State	Published - 2020

Keywords

Antifungal activity
Anvillea garcinii
Saudi medicinal plants
Sesquiterpene lactones

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10.3390/molecules25071730

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@article{376b68815fb940b2aab0d366b8a69bd3,

title = "Antibacterial and antifungal sesquiterpenoids from aerial parts of anvillea garcinii",

abstract = "Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia- 11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated fromthe leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3-9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1-9 were screened against seven different pathogenic microbes, and compounds 1-3 showed a potent antifungal activity.",

keywords = "Antifungal activity, Anvillea garcinii, Saudi medicinal plants, Sesquiterpene lactones",

author = "Shagufta Perveen and Jawaher Alqahtani and Raha Orfali and Aati, \{Hanan Y.\} and Al-Taweel, \{Areej M.\} and Ibrahim, \{Taghreed A.\} and Afsar Khan and \{Soliman Yusufoglu\}, Hasan and Abdel-Kader, \{Maged S.\} and Orazio Taglialatela-Scafati",

note = "Publisher Copyright: {\textcopyright} 2020 by the authors.",

year = "2020",

doi = "10.3390/molecules25071730",

language = "English",

volume = "25",

journal = "Molecules",

issn = "1420-3049",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "7",

}

TY - JOUR

T1 - Antibacterial and antifungal sesquiterpenoids from aerial parts of anvillea garcinii

AU - Perveen, Shagufta

AU - Alqahtani, Jawaher

AU - Orfali, Raha

AU - Aati, Hanan Y.

AU - Al-Taweel, Areej M.

AU - Ibrahim, Taghreed A.

AU - Khan, Afsar

AU - Soliman Yusufoglu, Hasan

AU - Abdel-Kader, Maged S.

AU - Taglialatela-Scafati, Orazio

PY - 2020

Y1 - 2020

N2 - Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia- 11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated fromthe leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3-9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1-9 were screened against seven different pathogenic microbes, and compounds 1-3 showed a potent antifungal activity.

AB - Two new sesquiterpenoids belonging to the guaiane, 4α,9α,10α-trihydroxyguaia- 11(13)en-12,6α-olide (1), and germacrane, 9β-hydroxyparthenolide-9-O-β-D-glucopyranoside (2), classes have been isolated fromthe leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3-9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1-9 were screened against seven different pathogenic microbes, and compounds 1-3 showed a potent antifungal activity.

KW - Antifungal activity

KW - Anvillea garcinii

KW - Saudi medicinal plants

KW - Sesquiterpene lactones

UR - https://www.scopus.com/pages/publications/85083281261

U2 - 10.3390/molecules25071730

DO - 10.3390/molecules25071730

M3 - Article

C2 - 32283756

AN - SCOPUS:85083281261

SN - 1420-3049

VL - 25

JO - Molecules

JF - Molecules

IS - 7

M1 - molecules25071730

ER -

Antibacterial and antifungal sesquiterpenoids from aerial parts of anvillea garcinii

Abstract

Keywords

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