TY - JOUR
T1 - Anti-hepatitis B virus activity of new 1,2,4-triazol-2-yl- and 1,3,4-oxadiazol-2-yl-2-pyridinone derivatives
AU - El-Essawy, Farag A.
AU - El-Sayed, Wael A.
AU - El-Kafrawy, Sherif A.
AU - Morshedy, Asmaa S.
AU - Abdel-Rahman, Adel H.
PY - 2008
Y1 - 2008
N2 - A number of 1,3,4-oxadiazole, 3-9, and 1,2,4-triazole derivatives, 13-15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from the substituted phenylthiosemicarbazide derivative 11 by treatment with sulfuric acid. The aryl hydrazone derivatives 10a-c were synthesized by reaction of the hydrazide 1 with the corresponding ketones. The thioalkyl derivatives 16a-e were prepared by akylation of the thiol derivatives 3 and 13 with different alkylating agents. The newly synthesized compounds were tested for their anti-HBV activity and some of these compounds showed high antiviral activity.
AB - A number of 1,3,4-oxadiazole, 3-9, and 1,2,4-triazole derivatives, 13-15, were synthesized starting form the acid hydrazide 1. The 1,3,4-thiadiazole derivative 12 was prepared from the substituted phenylthiosemicarbazide derivative 11 by treatment with sulfuric acid. The aryl hydrazone derivatives 10a-c were synthesized by reaction of the hydrazide 1 with the corresponding ketones. The thioalkyl derivatives 16a-e were prepared by akylation of the thiol derivatives 3 and 13 with different alkylating agents. The newly synthesized compounds were tested for their anti-HBV activity and some of these compounds showed high antiviral activity.
KW - 1,2,4-triazoles
KW - 1,3,4-oxadiazoles
KW - Anti-hepatitis B virus
UR - https://www.scopus.com/pages/publications/56249131101
U2 - 10.1515/znc-2008-9-1010
DO - 10.1515/znc-2008-9-1010
M3 - Article
C2 - 19040105
AN - SCOPUS:56249131101
SN - 0939-5075
VL - 63
SP - 667
EP - 674
JO - Zeitschrift fur Naturforschung - Section C Journal of Biosciences
JF - Zeitschrift fur Naturforschung - Section C Journal of Biosciences
IS - 9-10
ER -
