TY - JOUR
T1 - Anti-cancer potential of zerumbone in cancer and glioma
T2 - current trends and future perspectives
AU - Soroush, Alborz
AU - Pourhossein, Siavash
AU - Hosseingholizadeh, Dorrin
AU - Hjazi, Ahmed
AU - Shahhosseini, Reza
AU - Kavoosi, Haniyeh
AU - Kermanshahi, Nazgol
AU - Behnamrad, Parisa
AU - Ghavamikia, Nima
AU - Dadashpour, Mehdi
AU - Karkon Shayan, Sepideh
N1 - Publisher Copyright:
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2024/5
Y1 - 2024/5
N2 - Plant-derived immunomodulators and antitumor factors have appealed lots of attention from natural product scientists for their efficiency and safety and their important contribution to well-designed targeted drug action and delivery mechanisms. Zerumbone (ZER), the chief component of Zingiber zerumbet rhizomes, has been examined for its wide-spectrum in the treatment of multi-targeted diseases. The rhizomes have been used as food flavoring agents in numerous cuisines and in flora medication. Numerous in vivo and in vitro experiments have prepared confirmation of ZER as a potent immunomodulator as well as a potential anti-tumor agent. This review is an interesting compilation of all the important results of the research carried out to date to investigate the immunomodulatory and anticancer properties of ZER. The ultimate goal of this comprehensive review is to supply updated information and a crucial evaluation on ZER, including its chemistry and immunomodulating and antitumour properties, which may be of principal importance to supply a novel pathway for subsequent investigation to discover new agents to treat cancers and immune-related sickness. In addition, updated information on the toxicology of ZER has been summarized to support its safety profile.
AB - Plant-derived immunomodulators and antitumor factors have appealed lots of attention from natural product scientists for their efficiency and safety and their important contribution to well-designed targeted drug action and delivery mechanisms. Zerumbone (ZER), the chief component of Zingiber zerumbet rhizomes, has been examined for its wide-spectrum in the treatment of multi-targeted diseases. The rhizomes have been used as food flavoring agents in numerous cuisines and in flora medication. Numerous in vivo and in vitro experiments have prepared confirmation of ZER as a potent immunomodulator as well as a potential anti-tumor agent. This review is an interesting compilation of all the important results of the research carried out to date to investigate the immunomodulatory and anticancer properties of ZER. The ultimate goal of this comprehensive review is to supply updated information and a crucial evaluation on ZER, including its chemistry and immunomodulating and antitumour properties, which may be of principal importance to supply a novel pathway for subsequent investigation to discover new agents to treat cancers and immune-related sickness. In addition, updated information on the toxicology of ZER has been summarized to support its safety profile.
KW - Anti-tumor
KW - Glioma
KW - Immunomodulators
KW - Zerumbone
UR - http://www.scopus.com/inward/record.url?scp=85191039168&partnerID=8YFLogxK
U2 - 10.1007/s12032-024-02327-3
DO - 10.1007/s12032-024-02327-3
M3 - Review article
C2 - 38652207
AN - SCOPUS:85191039168
SN - 1357-0560
VL - 41
JO - Medical Oncology
JF - Medical Oncology
IS - 5
M1 - 125
ER -
