TY - JOUR
T1 - Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites' Carcinoma Activity
AU - Abd-Elghany, Amr A.
AU - Ahmed, Samya Mahmoud
AU - Masoud, Marwa A.
AU - Atia, Tarek
AU - Waggiallah, Hisham Ali
AU - El-Sakhawy, Mohamed A.
AU - Mohamad, Ebtesam A.
N1 - Publisher Copyright:
© 2022 The Authors. Published by American Chemical Society.
PY - 2022/11/1
Y1 - 2022/11/1
N2 - Current research is focused on cancer treatments other than chemotherapy medications, particularly those derived from natural sources. The goal of this work was to look at the anticancer and biomarker properties of a methanolic extract of Annona squamosa leaves and their extract-loaded noisome. A. squamosa leaves extract and their leaves extract-loaded noisome were prepared. Transmission electron microscopy was used to screen the size of the niosomes loaded with the A. squamosa L. leaves extract. The tumor size, blood picture (hemoglobin, red blood cells, white blood cells), liver functions, kidney function, oxidative stress, and inflammatory markers were evaluated to assess the potential anticancer activity of the A. squamosa leaves extract and A. squamosa leaves extract-loaded noisome in Ehrlich ascites carcinoma. A. squamosa L. leaves extract was found to be an effective anticancer treatment. The protective effect of the loaded extract showed more significant results. All treated groups showed a lower tumor volume compared to the positive control. Liver and kidney functions were improved, and inflammatory markers were decreased. Oxidative stress was improved in tumor, liver, and kidney tissues. A. squamosa leaves contain major anticancer compounds that in general help most enzymes of the liver and kidney and other injured organs to return to their normal levels.
AB - Current research is focused on cancer treatments other than chemotherapy medications, particularly those derived from natural sources. The goal of this work was to look at the anticancer and biomarker properties of a methanolic extract of Annona squamosa leaves and their extract-loaded noisome. A. squamosa leaves extract and their leaves extract-loaded noisome were prepared. Transmission electron microscopy was used to screen the size of the niosomes loaded with the A. squamosa L. leaves extract. The tumor size, blood picture (hemoglobin, red blood cells, white blood cells), liver functions, kidney function, oxidative stress, and inflammatory markers were evaluated to assess the potential anticancer activity of the A. squamosa leaves extract and A. squamosa leaves extract-loaded noisome in Ehrlich ascites carcinoma. A. squamosa L. leaves extract was found to be an effective anticancer treatment. The protective effect of the loaded extract showed more significant results. All treated groups showed a lower tumor volume compared to the positive control. Liver and kidney functions were improved, and inflammatory markers were decreased. Oxidative stress was improved in tumor, liver, and kidney tissues. A. squamosa leaves contain major anticancer compounds that in general help most enzymes of the liver and kidney and other injured organs to return to their normal levels.
UR - http://www.scopus.com/inward/record.url?scp=85140928579&partnerID=8YFLogxK
U2 - 10.1021/acsomega.2c03649
DO - 10.1021/acsomega.2c03649
M3 - Article
AN - SCOPUS:85140928579
SN - 2470-1343
VL - 7
SP - 38436
EP - 38447
JO - ACS Omega
JF - ACS Omega
IS - 43
ER -
