An Efficient Synthesis of 1-(1,3-Dioxoisoindolin-2-yl)-3-aryl Urea Analogs as Anticancer and Antioxidant Agents: An Insight into Experimental and In Silico Studies

Pharmacology, Toxicology and Pharmaceutical Science

• Antioxidant 100%
• Malignant Neoplasm 100%
• Epidermal Growth Factor Receptor 100%
• IC50 100%
• Antioxidant Capacity 66%
• Melanoma 66%
• Absorption-Distribution-Metabolism-Excretion Toxicity 33%
• Breast Cancer 33%
• Imatinib 33%
• Cytotoxicity 33%
• Lipinski's Rule of Five 33%
• Functional Group 33%
• Immunotoxicity 33%
• Hepatotoxicity 33%
• Hydrogen Bond 33%
• Mutagenicity 33%
• Non Small Cell Lung Cancer 33%
• Molecular Target 33%
• Prostate Cancer 33%
• Kidney Cancer 33%
• Thalidomide 33%
• Central Nervous System Cancer 33%

Chemistry

• Antioxidant Agent 100%
• IC50 100%
• Antioxidant Capacity 66%
• Inhibition of Growth 33%
• Imatinib 33%
• Immunotoxicity 33%

Biochemistry, Genetics and Molecular Biology

• In silico ADMET 25%
• Mutagenicity 25%
• Erlotinib 25%